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Gene expression and copy number variation in common complex diseases
(2010-12-17)
Common, complex diseases are not caused by a single gene mutation but rather have genetic and environmental components. As a subset, autoimmune diseases also possess robust gene expression signatures that have both genetic ...
Early Indices of Auditory Pathology in Young Adults with Type-1 Diabetes
(2010-09-15)
This project is concerned with the relationship between type-1 diabetes and auditory pathology. In this dissertation I compared hearing sensitivity, cochlear function, and peripheral auditory neural function (afferent and ...
The role of insulin and Akt in the regulation of the norepinephrine transporter and monoamine homeostasis
(2010-07-15)
Monoamine signaling in the central nervous system plays an essential role in circuits involving attention, mood, memory, and stress as well as providing pivotal support for autonomic function in the peripheral nervous ...