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Variables that influence transcription factor-mediated acinar to beta cell reprogramming
(2017-02-24)
Reprogramming of pancreatic cells into new beta-like cells is a potential therapy for Type 1 diabetes. Pancreatic acinar cells are an appealing target for cellular reprogramming since they are abundant, derived from a ...
Synaptotagmin IV and Myt factors promote β-cell functional maturation and maintenance
(2017-03-31)
Both type I and type II diabetes are related to β-cell defects in the pancreatic islet of Langerhans. Deriving β-cells from stem cells and other mature cell types provides an important cell source for transplantation-based ...
Modulation of Beta-Cell Intrinsic and Extrinsic Characteristics by CTGF to Promote Beta-Cell Mass Regeneration.
(2015-03-25)
As diabetes continues to affect millions of people within the United States, identification of novel factors that may enhance beta-cell proliferation and mass regeneration in vivo is critical. Our lab previously demonstrated ...
Examination of Hnf6 and downstream effectors in postnatal endocrine function
(2013-10-01)
CELL AND DEVELOPMENTAL BIOLOGY
Examination of Hnf6 and downstream effectors
in postnatal endocrine function
Kathryn D. Henley
Dissertation under the direction of Professor Maureen Gannon
The pancreas is an ...