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Analysis of Methylglyoxal Toxicity in Hybridoma Cell Culture
(2004-04-09)
Methylglyoxal (MG) is a toxic compound which is produced in cells as a byproduct of glycolysis. Recently, the compound has been suggested as a damaging agent in batch cultures of production cell lines. In the current ...
Biomolecular Signatures of Disease via Ion Mobility and Mass Spectrometry Techniques
(2014-04-01)
Ion mobility-mass spectrometry (IM-MS) applies a gas-phase separation on the basis of structure prior to the MS, enabling separation of different types of biomolecules based on their gas-phase packing efficiencies. For ...
The Relationship Between Diabetes and Depressive Symptoms in the Southern Community Cohort Study
(2005-04-19)
The goal of this study was to examine the relationship between diabetes and depressive symptoms in the Southern Community Cohort Study (SCCS). The SCCS is a prospective, community-based cohort study examining racial ...
The Effects of Obesity, Weight Loss, and Weight Cycling on the Immunometabolic Properties of Mouse Adipose Tissue
(2013-04-11)
Obesity is a prevalent disorder that increases the risk of developing many metabolic diseases, including insulin resistance (IR) and type 2 diabetes. Research conducted in the past decade has shown that accumulation of ...
The role of insulin and Akt in the regulation of the norepinephrine transporter and monoamine homeostasis
(2010-07-15)
Monoamine signaling in the central nervous system plays an essential role in circuits involving attention, mood, memory, and stress as well as providing pivotal support for autonomic function in the peripheral nervous ...
Variables that influence transcription factor-mediated acinar to beta cell reprogramming
(2017-02-24)
Reprogramming of pancreatic cells into new beta-like cells is a potential therapy for Type 1 diabetes. Pancreatic acinar cells are an appealing target for cellular reprogramming since they are abundant, derived from a ...
Synaptotagmin IV and Myt factors promote β-cell functional maturation and maintenance
(2017-03-31)
Both type I and type II diabetes are related to β-cell defects in the pancreatic islet of Langerhans. Deriving β-cells from stem cells and other mature cell types provides an important cell source for transplantation-based ...
Modulation of Beta-Cell Intrinsic and Extrinsic Characteristics by CTGF to Promote Beta-Cell Mass Regeneration.
(2015-03-25)
As diabetes continues to affect millions of people within the United States, identification of novel factors that may enhance beta-cell proliferation and mass regeneration in vivo is critical. Our lab previously demonstrated ...
Early Indices of Auditory Pathology in Young Adults with Type-1 Diabetes
(2010-09-15)
This project is concerned with the relationship between type-1 diabetes and auditory pathology. In this dissertation I compared hearing sensitivity, cochlear function, and peripheral auditory neural function (afferent and ...
Autoreactive B cell development in the periphery
(2006-10-09)
Self-reactive B lymphocytes are frequently produced as a consequence of B cell antigen receptor rearrangement. Autoreactive B cells that are not eliminated or inactivated by tolerance mechanisms survive and mature in the ...