Browsing Collaborative Research by Title

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Dissymmetry Factor Spectral Analysis Can Provide Useful Diastereomer Discrimination_Chiral Molecular Structure of an Analogue of (-)-Crispine A

Johnson, Jordan L.; Nair, Divya Sadasivan; Pillai, Sarath Muraleedharan; Johnson, Didimos; Kallingathodii, Zabeera; Ibnusaud, Ibrahim; Polavarapu, Prasad L. (ACS Omega, 2019-04)

(1R,10bR)-1'-((R) - 1,2- Dihydroxyethyl) -1-hydrox-8,9-dmiethoxy1,5,6,10b-tetrahydropyrrolo [2,1-a]-isoquinolin-3(2H)-one, an analogue of (-)-crispine A, with three stereogenic centers is synthesized and its absolute ...
Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy

Waterson, Alex G. (Cell Reports, 2020-02-11)

The reliance of many cancers on aerobic glycolysis has stimulated efforts to develop lactate dehydrogenase (LDH) inhibitors. However, despite significant efforts, LDH inhibitors (LDHi) with sufficient specificity and in ...