Department of Chemistry
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Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy (Cell Reports, 2020-02-11)The reliance of many cancers on aerobic glycolysis has stimulated efforts to develop lactate dehydrogenase (LDH) inhibitors. However, despite significant efforts, LDH inhibitors (LDHi) with sufficient specificity and in ...
Dissymmetry Factor Spectral Analysis Can Provide Useful Diastereomer Discrimination_Chiral Molecular Structure of an Analogue of (-)-Crispine A (ACS Omega, 2019-04)(1R,10bR)-1'-((R) - 1,2- Dihydroxyethyl) -1-hydrox-8,9-dmiethoxy1,5,6,10b-tetrahydropyrrolo [2,1-a]-isoquinolin-3(2H)-one, an analogue of (-)-crispine A, with three stereogenic centers is synthesized and its absolute ...
Interlaced crystals having a perfect Bravais lattice and complex chemical order revealed by real-space crystallography (2014-11-14)The search for optimal thermoelectric materials aims for structures in which the crystalline order is disrupted to lower the thermal conductivity without degradation of the electron conductivity. Here we report the synthesis ...