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Investigations of Orthosomycin Biosynthesis
(2015-12-16)
Orthosomycins are highly decorated oligosaccharides with potent activity against a variety of Gram-positive bacteria including methicillin-resistant staphylococci and vancomycin-resistant enterococci. The research in this ...
Spatiotemporal Dynamics of Binocular Rivalry
(2008-12-16)
When two eyes view dissimilar monocular images, those two images resist binocular combination and, instead, engage in competitive interactions that produce fluctuations in perception over time; this phenomenon is called ...
BMP Signaling in High Grade Gliomas
(2015-12-16)
Improved therapies for high grade gliomas (HGG) are urgently needed, as the median survival for grade IV gliomas is just 15 months after treatment with surgery, chemotherapy and radiation. Recently, bone morphogenetic ...
Toward a womanist homiletic: Katie Cannon, Alice Walker and emancipatory proclamation
(2005-12-15)
RELIGION
TOWARD A WOMANIST HOMILETIC: KATIE CANNON, ALICE WALKER AND EMANCIPATORY PROCLAMATION
Donna E. Allen
Dissertation under the direction of Professor John S. McClure
This project builds on the work of ...
Strain-specific alleles of <i>Phox2B</i> differentially modify <i>Sox10<sup>Dom</sup></i> aganglionosis
(2011-02-15)
Hirschsprung disease (HSCR) is characterized by a lack of enteric ganglia in a variable portion of the distal bowel. The complex inheritance pattern of this disorder has led researchers to focus on genetic effects other ...
Molecular Mechanism of Prothrombin Activation by von Willebrand Factor-Binding Protein
(2010-01-04)
The studies in this dissertation defined the molecular mechanism of prothrombin (ProT) activation by a recently-identified Staphylococcus aureus exoprotein, von Willebrand factor-binding protein (VWbp). We demonstrated ...
In the Balance: Natural vs. Embanked Landscapes on the Ganges Brahmaputra Tidal Delta Plain
(2013-12-18)
The future of deltas worldwide will be determined by a balance of sedimentation, subsidence and sea-level rise, in addition to human-caused perturbations. The Ganges-Brahmaputra delta is perceived to be at great risk to ...
Micro-Price Dynamics in Small Open Economies: Lessons from Ecuador
(2019-01-02)
From 1998 to 2003, Ecuador experienced large macroeconomic fluctuations ending with a period of stabilization under a dollarized economy. This dissertation exploits these fluctuations and a novel dataset of micro-prices ...
Knowledge-Driven Genome-Wide Analysis of Multigenic Interactions Impacting HDL Cholesterol Level
(2010-12-21)
Growing interest and burgeoning technology for discovering genetic mechanisms that influence disease processes have ushered in a flood of genetic association studies over the last decade, yet little heritability in highly ...
The Role of Epoxygenated Fatty Acids in Diabetic Retinopathy
(2016-12-15)
Diabetic retinopathy (DR) is the leading cause of blindness in working age Americans. The early stages of DR pathogenesis include chronic inflammation, which can eventually lead to the development of later stages of the ...