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Structural and biochemical characterization of yeast alkylpurine DNA glycosylases
(2013-03-04)
Work presented in this dissertation details structural and biochemical characterization of three yeast alkylpurine DNA glycosylases – Mag1 and Mag2 from S. pombe and Mag from S. cerevisiae. I determined high resolution ...
Evasion of adaptive immune defenses by the lethal chytrid fungus Batrachochytrium dendrobatidis
(2014-03-04)
In the sixth mass extinction, amphibians are being lost in greater numbers than almost any other taxon. The deadly skin disease, chytridiomycosis, has taken a great toll on amphibian populations around the globe. ...
Phospholipid selection and transport by P4-ATPases
(2013-03-01)
The plasma membrane of eukaryotic cells displays a distinctive asymmetry of the component phospholipids. Type-IV P-type ATPases (P4-ATPases) flip specific phospholipids across the membrane bilayer to establish and maintain ...
Fgf Signaling Governs the Differentiation of Parapineal Neurons in Zebrafish
(2013-03-29)
Parapineal precursors arise from the medially located pineal complex anlage and migrate to the left side of the brain. Published data implicates Fgf8a in the migration of parapineal cells away from the midline of the pineal ...
The Impact of Maternally Transmitted Microbes on Animal Evolution
(2016-02-29)
Maternally transmitted microbes that infect host germ cells are perfectly poised to influence animal genome evolution, either directly through horizontal gene transfer or indirectly through selection for host genetic ...
Auto-Inhibitory Mechanism for the Regulation of a P4-ATPase
(2014-03-05)
Vesicular transport of proteins is a process essential for cell health and viability. Integral membrane proteins, called phospholipid flippases, play important roles in the formation of transport vesicles at sites of ...
Inhibition of GABA Initiates Retina Regeneration in the Zebrafish
(2016-07-27)
Retina damage or disease in humans often leads to reactive gliosis, preventing the formation of new cells and resulting in visual impairment or blindness. Currently, treatments are being developed to stimulate repair or ...
Exploring the importance of mosquito hemocoelic and salivary gland components during host-pathogen interactions
(2012-09-27)
Traversal of the hemocoel, avoiding or surviving interactions with the insect’s innate immune system, invasion of the female mosquito’s salivary glands, and injection into the vertebrate host, are necessary steps for disease ...
Analysis of ZNF9 function in cap-independent translation and myotonic dystrophy type 2
(2010-08-13)
Myotonic dystrophy type 2 (DM2) is an autosomal dominant human disease caused by the expansion of a tetranucleotide repeat in the first intron of the ZNF9 gene. While multiple studies link nucleotide expansions such as ...
Contributions to telomerase anchor-site and template/primer alignment functions by yeast TERT residue E76
(2011-09-02)
This project explores the synthesis of heterogeneous G1-3T yeast telomere sequences by the enzyme telomerase. I demonstrate that a mutant in the essential N-terminal TEN domain of Est2p (telomerase reverse transciptase), ...