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A chemical genetic approach to interrogate the staphylococcal heme sensing system
(2016-11-23)
Staphylococcus aureus is a Gram-positive pathogen that contributes to significant morbidity and mortality worldwide. In order to successfully colonize the host, S. aureus requires heme as a nutrient iron source and as a ...
Novel stable isotope methods to quantify glucose metabolism
(2016-11-18)
The development, validation, and application of novel methods to quantify glucose metabolism are presented in this thesis. The methodologies use stable isotope tracers, gas chromatography-mass spectrometry, and mathematical ...
The Role of Epoxygenated Fatty Acids in Diabetic Retinopathy
(2016-12-15)
Diabetic retinopathy (DR) is the leading cause of blindness in working age Americans. The early stages of DR pathogenesis include chronic inflammation, which can eventually lead to the development of later stages of the ...
Crystal-Bound Ligands in Nanocrystal Synthesis
(2016-12-19)
Semiconductor nanocrystals are a desirable class of nanomaterials for electronic, energy conversion, and biomedical applications. The work presented in this thesis aids in the understanding of the fundamental chemistry ...
Engineering Light-matter Interaction in Dielectric Nanophotonic Resonators
(2016-12-21)
Engineering light-matter interaction at the nanoscale has the promise to enable technological advances in a wide range of technological applications, including biomolecular sensing, communication, quantum optics, displays, ...
Molecular Genetic Dissection of the RNA Polymerase II Transcription Factor D (TFIID) Subunit Taf2
(2016-12-13)
The evolutionarily conserved 14-subunit RNA Polymerase II Transcription Factor D (TFIID) complex is composed of TATA-box Binding Protein (TBP) and 13 TBP-associated factors (Tafs). In Saccharomyces cerevisiae, TFIID is ...
High Performance Numerical Simulations To Support System Level Design
(2016-01-12)
Cyber-physical systems (CPS) represent a class of complex engineered systems where functionality and behavior emerge through the interaction between the computational and physical domains. Simulation provides design ...
Desire, Knowledge, and the Origins of Self-Consciousness: A Theological Account in Conversation with Augustine, Aquinas, and Freud
(2016-11-21)
This dissertation proposes a novel way of reconceptualizing the nature, origins, and theological significance of egoic self-consciousness that successfully eludes the deeply-rooted impulse to ground the “self” circularly ...
Algorithms and Techniques for Managing Extensibility in Cyber-Physical Systems
(2016-11-22)
Over the past decades, distributed computing paradigm has evolved from smaller and mostly homogeneous clusters to the current notion of ubiquitous computing, which consists of dynamic and heterogeneous resources in large ...
Functional implications of electrophilic protein adducts
(2016-11-17)
Oxidative stress is a contributing factor in a number of chronic diseases, including cancer, atherosclerosis, and neurodegenerative diseases. Lipid peroxidation that occurs during periods of oxidative stress and decomposition ...