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Biomolecular Signatures of Disease via Ion Mobility and Mass Spectrometry Techniques
(2014-04-01)
Ion mobility-mass spectrometry (IM-MS) applies a gas-phase separation on the basis of structure prior to the MS, enabling separation of different types of biomolecules based on their gas-phase packing efficiencies. For ...
The Effects of Obesity, Weight Loss, and Weight Cycling on the Immunometabolic Properties of Mouse Adipose Tissue
(2013-04-11)
Obesity is a prevalent disorder that increases the risk of developing many metabolic diseases, including insulin resistance (IR) and type 2 diabetes. Research conducted in the past decade has shown that accumulation of ...
The role of insulin and Akt in the regulation of the norepinephrine transporter and monoamine homeostasis
(2010-07-15)
Monoamine signaling in the central nervous system plays an essential role in circuits involving attention, mood, memory, and stress as well as providing pivotal support for autonomic function in the peripheral nervous ...
Variables that influence transcription factor-mediated acinar to beta cell reprogramming
(2017-02-24)
Reprogramming of pancreatic cells into new beta-like cells is a potential therapy for Type 1 diabetes. Pancreatic acinar cells are an appealing target for cellular reprogramming since they are abundant, derived from a ...
Synaptotagmin IV and Myt factors promote β-cell functional maturation and maintenance
(2017-03-31)
Both type I and type II diabetes are related to β-cell defects in the pancreatic islet of Langerhans. Deriving β-cells from stem cells and other mature cell types provides an important cell source for transplantation-based ...
Modulation of Beta-Cell Intrinsic and Extrinsic Characteristics by CTGF to Promote Beta-Cell Mass Regeneration.
(2015-03-25)
As diabetes continues to affect millions of people within the United States, identification of novel factors that may enhance beta-cell proliferation and mass regeneration in vivo is critical. Our lab previously demonstrated ...
Early Indices of Auditory Pathology in Young Adults with Type-1 Diabetes
(2010-09-15)
This project is concerned with the relationship between type-1 diabetes and auditory pathology. In this dissertation I compared hearing sensitivity, cochlear function, and peripheral auditory neural function (afferent and ...
Examination of Hnf6 and downstream effectors in postnatal endocrine function
(2013-10-01)
CELL AND DEVELOPMENTAL BIOLOGY
Examination of Hnf6 and downstream effectors
in postnatal endocrine function
Kathryn D. Henley
Dissertation under the direction of Professor Maureen Gannon
The pancreas is an ...
Glutotoxic and Lipotoxic Consequences for Human β Cell Function In Vivo
(2015-10-20)
Diabetes is characterized by excess levels of glucose and lipid in the blood, which have been proposed to directly and negatively impact islet β cells, exacerbating symptoms and promoting disease progression. Our understanding ...
Examining the roles of MafB in the pancreatic islet
(2015-10-20)
Analysis of MafB-/- mice suggested that this transcription factor was essential to islet α- and β-cell formation during development, although the postnatal physiological impact could not be studied because these mutants ...