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Now showing items 11-20 of 27
Modulation of Beta-Cell Intrinsic and Extrinsic Characteristics by CTGF to Promote Beta-Cell Mass Regeneration.
(2015-03-25)
As diabetes continues to affect millions of people within the United States, identification of novel factors that may enhance beta-cell proliferation and mass regeneration in vivo is critical. Our lab previously demonstrated ...
Examination of Hnf6 and downstream effectors in postnatal endocrine function
(2013-10-01)
CELL AND DEVELOPMENTAL BIOLOGY
Examination of Hnf6 and downstream effectors
in postnatal endocrine function
Kathryn D. Henley
Dissertation under the direction of Professor Maureen Gannon
The pancreas is an ...
Early Indices of Auditory Pathology in Young Adults with Type-1 Diabetes
(2010-09-15)
This project is concerned with the relationship between type-1 diabetes and auditory pathology. In this dissertation I compared hearing sensitivity, cochlear function, and peripheral auditory neural function (afferent and ...
Glutotoxic and Lipotoxic Consequences for Human β Cell Function In Vivo
(2015-10-20)
Diabetes is characterized by excess levels of glucose and lipid in the blood, which have been proposed to directly and negatively impact islet β cells, exacerbating symptoms and promoting disease progression. Our understanding ...
Examining the roles of MafB in the pancreatic islet
(2015-10-20)
Analysis of MafB-/- mice suggested that this transcription factor was essential to islet α- and β-cell formation during development, although the postnatal physiological impact could not be studied because these mutants ...
The pathophysiology and functionality of metabolic microRNAs in Type 2 Diabetes Mellitus.
(2018-10-31)
microRNAs (miRNA) have been shown to be critical players in metabolism. While most miRNAs studies have focused on their functional role within cells, miRNAs are also found extracellularly and have been proposed to participate ...
Structure-Function Analyses of Prostaglandin E2 Receptor Subtypes 1 and 3
(2012-11-21)
Prostaglandin E2 (PGE2) is a lipid autacoid, which is an oxidative metabolite of arachidonic acid synthesized by cyclooxygenase and prostaglandin E synthases. PGE2 is proposed to mediate in part the pathophysiology of ...
The Effects of Obesity, Weight Loss, and Weight Cycling on the Immunometabolic Properties of Mouse Adipose Tissue
(2013-04-11)
Obesity is a prevalent disorder that increases the risk of developing many metabolic diseases, including insulin resistance (IR) and type 2 diabetes. Research conducted in the past decade has shown that accumulation of ...
Biomolecular Signatures of Disease via Ion Mobility and Mass Spectrometry Techniques
(2014-04-01)
Ion mobility-mass spectrometry (IM-MS) applies a gas-phase separation on the basis of structure prior to the MS, enabling separation of different types of biomolecules based on their gas-phase packing efficiencies. For ...
Multiple roles for Ascorbic Acid in the Brain: Transporter Regulation, Neurotransmitter Synthesis, and Brain Endothelial Cell Stability
(2014-04-17)
The roles for ascorbic acid (ASC) in regulation of its transporter, in neurotransmitter synthesis, and in brain endothelial cell barrier permeability were investigated in the brain. First, during mouse development, levels ...