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Identification and Characterization of p53 Target Genes
(2010-06-16)
After 30 years of research, p53 is recognized as one of the most frequently mutated genes in human cancer (Baker et al, 1989; Nigro et al, 1989; Momand et al, 2000; Daujat et la, 2001). To accomplish its tumor suppressive ...
The Evolution of Fosfomycin Resistance Enzyme, FosA, from Pseudomonas aeruginosa and the Development of a High-Throughput Screen for the Discovery of Bioactive Inhibitors
(2010-06-04)
Fosfomycin is a broad-spectrum antibiotic that has been underused due to the nature of the resistance mounted against it by various microorganisms. The work presented here elucidates the structure function relationship ...
The Tarsqi Toolkit’s Recognition of Temporal Expressions within Medical Documents
(2010-05-25)
To diagnose and treat patients, clinicians concern themselves with a complex set
of events. They need to know when, how long, and in what sequence certain events
occur. An automated means of extracting temporal meaning in ...
Novel and diverse roles of STRAP in maintenance of mesenchymal morphology and GSK3Beta signaling.
(2010-06-04)
STRAP inhibits transforming growth factor-Beta (TGF-Beta) signaling and enhances tumorigenicity. The aim of our current research project was to identify novel TGF-Beta independent functions of STRAP. STRAP acts as a scaffold ...
Effect of Self-regulated Strategy Development Story-writing Instruction: Adult School Volunteers in Action
(2010-06-23)
A large majority of students continue to fall below basic writing levels in spite of the existence of effective supplemental writing treatments (e.g., Self-Regulated Strategy Development model; SRSD; Harris, Graham, and ...
“Mer all sin kölle”: Colognian identity, Colognian carnival and the evolution of Heimatwerte.
(2010-06-29)
This paper explores the festival of carnival in the German city of Cologne from its beginnings in the Middle Ages to its modern celebration. It focuses on its development and convergence with local Heimat-identities and ...
Kinetic Analysis of the Multi-Step Cytochrome P450 1A2 and 19A1 Enzymes
(2010-06-23)
The kinetic characterization of cytochrome P450s that catalyze multi-step, sequential reactions is the focus of this work. Two novel substrates were identified for P450 1A2, one of which showed a high degree of homotropic ...
Children's use of pragmatic competence as evidence for the reliability of an information source
(2010-04-20)
Two aspects of children’s understanding of Gricean maxims were investigated. First, children’s awareness of adherence to the maxims of quality and relation was tested in two separate conditions. Second, children’s use of ...
Emotion Regulation, Coping, and Executive Functioning in Risk for Depression: An Integrative Approach
(2010-04-10)
The current study analyzes the relationship between executive functioning, emotion regulation, and patterns of coping strategies in older adolescents and young adults. Results from this study indicate that although there ...
Visual attention mechanisms underlying the emotional dot probe task
(2010-04-10)
The emotional dot probe paradigm has been used extensively to explore attentional biases. Behavioral reaction times are the most common measurement, but have been criticized for being a rather indirect measure of attentional ...