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BMP Signaling in High Grade Gliomas
(2015-12-16)
Improved therapies for high grade gliomas (HGG) are urgently needed, as the median survival for grade IV gliomas is just 15 months after treatment with surgery, chemotherapy and radiation. Recently, bone morphogenetic ...
Strain-specific alleles of <i>Phox2B</i> differentially modify <i>Sox10<sup>Dom</sup></i> aganglionosis
(2011-02-15)
Hirschsprung disease (HSCR) is characterized by a lack of enteric ganglia in a variable portion of the distal bowel. The complex inheritance pattern of this disorder has led researchers to focus on genetic effects other ...
Molecular Mechanism of Prothrombin Activation by von Willebrand Factor-Binding Protein
(2010-01-04)
The studies in this dissertation defined the molecular mechanism of prothrombin (ProT) activation by a recently-identified Staphylococcus aureus exoprotein, von Willebrand factor-binding protein (VWbp). We demonstrated ...
In the Balance: Natural vs. Embanked Landscapes on the Ganges Brahmaputra Tidal Delta Plain
(2013-12-18)
The future of deltas worldwide will be determined by a balance of sedimentation, subsidence and sea-level rise, in addition to human-caused perturbations. The Ganges-Brahmaputra delta is perceived to be at great risk to ...
Micro-Price Dynamics in Small Open Economies: Lessons from Ecuador
(2019-01-02)
From 1998 to 2003, Ecuador experienced large macroeconomic fluctuations ending with a period of stabilization under a dollarized economy. This dissertation exploits these fluctuations and a novel dataset of micro-prices ...
Knowledge-Driven Genome-Wide Analysis of Multigenic Interactions Impacting HDL Cholesterol Level
(2010-12-21)
Growing interest and burgeoning technology for discovering genetic mechanisms that influence disease processes have ushered in a flood of genetic association studies over the last decade, yet little heritability in highly ...
The Role of Epoxygenated Fatty Acids in Diabetic Retinopathy
(2016-12-15)
Diabetic retinopathy (DR) is the leading cause of blindness in working age Americans. The early stages of DR pathogenesis include chronic inflammation, which can eventually lead to the development of later stages of the ...
The serpent without shame: economic development and change in the Afro-Ecuadorian communities of northwestern Esmeraldas
(2011-12-19)
Implicit in definitions and in the practice of community and economic development are assumptions that the processes and outcomes will improve the human condition. In the towns, riverine, and mangrove swamp communities of ...
Crystal-Bound Ligands in Nanocrystal Synthesis
(2016-12-19)
Semiconductor nanocrystals are a desirable class of nanomaterials for electronic, energy conversion, and biomedical applications. The work presented in this thesis aids in the understanding of the fundamental chemistry ...
Hybrid phase-changing nanostructures: from reconfigurable plasmonic devices to ultrafast dynamics
(2012-12-20)
Ultrafast photoinduced phase transitions in quantum materials could revolutionize data-storage and telecommunications technologies by modulating transport in integrated nanocircuits at terahertz speeds. In phase-changing ...