Browsing Research reports by Title
Now showing items 2-21 of 24
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(Journal of the American Heart Association, 2019-08-06)Background-Subtle reductions in cardiac output relate to lower cerebral blood flow, especially in regions where Alzheimer's disease pathology first develops. Apolipoprotein E (APOE)-epsilon 4 is a genetic susceptibility ...
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(Journal of the American Heart Association, 2019-12-03)Background The New York Heart Association (NYHA) classification has served as a fundamental tool for risk stratification of heart failure (HF) and determines clinical trial eligibility and candidacy for drugs and devices. ...
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(Journal of the American Heart Association, 2019-09-23)Background-Identification of occult diastolic dysfunction often requires invasive right heart catheterization with provocative maneuvers such as fluid challenge. Non-invasive predictors of occult diastolic dysfunction have ...
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(Hypertension, 2020-02)While hypertension and inflammation are physiologically inter-related, the effect of therapies that specifically target inflammation on blood pressure is uncertain. The recent CANTOS (Canakinumab Anti-inflammatory Thrombosis ...
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(2020-01-07)Background In infants with ductal-dependent pulmonary blood flow, the impact of palliation strategy on interstage growth and feeding regimen is unknown. Methods and Results This was a retrospective multicenter ...
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(Journal of the American Heart Association, 2019-08-20)Background-alpha Carboxyl terminus 1 (alpha CT1) is a 25-amino acid therapeutic peptide incorporating the zonula occludens-1 (ZO-1)-binding domain of connexin 43 (Cx43) that is currently in phase 3 clinical testing on ...
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(JACC-Heart Failure, 2020-03)Whereas multiple national, international, and trial registries for heart failure have been created, international standards for clinical assessment and outcome measurement do not currently exist. The working group's objective ...
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(Journal of the American Heart Association, 2019-06-18)
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(2019-12-17)Background Data are limited on use patterns of low-dose aspirin and its role for primary prevention of cardiovascular disease (CVD) in different racial and ethnic groups. Methods and Results Overall, 65 231 ...
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(PULMONARY CIRCULATION, 2019-06)Low-grade albuminuria, determined by the urinary albumin to creatinine ratio, has been linked to systemic vascular dysfunction and is associated with cardiovascular mortality. Pulmonary arterial hypertension is related to ...
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(JRSM Cardiovascular Disease, 2020-02)Purpose Chronic thromboembolic pulmonary hypertension is characterized by incomplete thrombus resolution following acute pulmonary embolism, leading to pulmonary hypertension and right ventricular dysfunction. Conditions ...
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(Journal of the American Heart Association, 2019-08-20)Background-Duchenne muscular dystrophy (DMD) is an X-linked disease that causes progressive muscle weakness. Affected boys typically die from respiratory or cardiac failure. Golden retriever muscular dystrophy (GRMD) is ...
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(Journal of the American Heart Association, 2019-05-07)Background-PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitors effectively lower LDL (low-density lipoprotein) cholesterol and have been shown to reduce cardiovascular outcomes in high-risk patients. We used ...
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(Journal of the American Heart Association, 2019-07-16)Background-Cardiovascular disease is a major cause of morbidity and mortality in children with chronic kidney disease. We sought to determine the prevalence of cardiovascular risk factors in children with glomerular disease ...
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(Journal of the American Heart Association, 2019-03-19)Background-Prior studies relating proteomics markers to incident AF screened for limited numbers of proteins. Methods and Results-We performed proteomics assays among participants from the Framingham Heart Study Offspring ...
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(European Journal of Heart Failure, 2019-07)Aims Heart failure ( HF) is associated with considerable symptom burden and impairment in physical functioning and quality of life. The sodium-glucose co-transporter 2 inhibitor empagliflozin reduced the risk of HF ...
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(PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY, 2019-07)Background Reactive atrial-based antitachycardia pacing (rATP) aims to terminate atrial tachyarrhythmia/atrial fibrillation (AT/AF) episodes when they spontaneously organize to atrial flutter or atrial tachycardia; however, ...
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(Journal of the American Heart Association, 2020-01-21)
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(Molecular Metabolism, 2023-01-13)Objective: Oxidative stress contributes to the development of insulin resistance (IR) and atherosclerosis. Peroxidation of lipids produces reactive dicarbonyls such as Isolevuglandins (IsoLG) and malondialdehyde (MDA) that ...
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(Pulmonary Circulation, 2020-01)Pulmonary arterial hypertension (PAH) is a sexually dimorphic disease that for unknown reasons affects women more than men. The role of estrogens, both endogenous and exogenous, and reproductive factors in this female ...