Cardiovascular Medicine
The Division is comprised of more than 140 faculty members dedicated to understanding, preventing, and treating cardiovascular disease.A fundamental component of our mission is research aimed at understanding the causes of cardiovascular disease and the translation of this knowledge to improve patient care.
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Recent Submissions
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(Molecular Metabolism, 2023-01-13)Objective: Oxidative stress contributes to the development of insulin resistance (IR) and atherosclerosis. Peroxidation of lipids produces reactive dicarbonyls such as Isolevuglandins (IsoLG) and malondialdehyde (MDA) that ...
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(Journal of the American Heart Association, 2019-12-03)Background The New York Heart Association (NYHA) classification has served as a fundamental tool for risk stratification of heart failure (HF) and determines clinical trial eligibility and candidacy for drugs and devices. ...
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(2020-01-07)Background In infants with ductal-dependent pulmonary blood flow, the impact of palliation strategy on interstage growth and feeding regimen is unknown. Methods and Results This was a retrospective multicenter ...
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(JACC-Heart Failure, 2020-03)Whereas multiple national, international, and trial registries for heart failure have been created, international standards for clinical assessment and outcome measurement do not currently exist. The working group's objective ...
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(Journal of the American Heart Association, 2020-01-21)
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(Pulmonary Circulation, 2020-01)Pulmonary arterial hypertension (PAH) is a sexually dimorphic disease that for unknown reasons affects women more than men. The role of estrogens, both endogenous and exogenous, and reproductive factors in this female ...
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(2019-12-17)Background Data are limited on use patterns of low-dose aspirin and its role for primary prevention of cardiovascular disease (CVD) in different racial and ethnic groups. Methods and Results Overall, 65 231 ...
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(JRSM Cardiovascular Disease, 2020-02)Purpose Chronic thromboembolic pulmonary hypertension is characterized by incomplete thrombus resolution following acute pulmonary embolism, leading to pulmonary hypertension and right ventricular dysfunction. Conditions ...
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(Hypertension, 2020-02)While hypertension and inflammation are physiologically inter-related, the effect of therapies that specifically target inflammation on blood pressure is uncertain. The recent CANTOS (Canakinumab Anti-inflammatory Thrombosis ...
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2019 HRS/EHRA/APHRS/LAHRS expert consensus statement on catheter ablation of ventricular arrhythmias (Heart Rhythm, 2020-01)Ventricular arrhythmias are an important cause of morbidity and mortality and come in a variety of forms, from single premature ventricular complexes to sustained ventricular tachycardia and fibrillation. Rapid developments ...
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(Journal of the American Heart Association, 2019-05-07)Background-PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitors effectively lower LDL (low-density lipoprotein) cholesterol and have been shown to reduce cardiovascular outcomes in high-risk patients. We used ...
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(Journal of the American Heart Association, 2019-06-04)Background-Elevated total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglycerides, and non-high-density lipoprotein cholesterol (non-HDL-C) and low high-density lipoprotein cholesterol (HDL-C) ...
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(Journal of the American Heart Association, 2019-07-16)Background-Cardiovascular disease is a major cause of morbidity and mortality in children with chronic kidney disease. We sought to determine the prevalence of cardiovascular risk factors in children with glomerular disease ...
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(Journal of the American Heart Association, 2019-08-06)Background-Subtle reductions in cardiac output relate to lower cerebral blood flow, especially in regions where Alzheimer's disease pathology first develops. Apolipoprotein E (APOE)-epsilon 4 is a genetic susceptibility ...
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(Journal of the American Heart Association, 2019-06-18)
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(Journal of the American Heart Association, 2019-03-19)Background-Prior studies relating proteomics markers to incident AF screened for limited numbers of proteins. Methods and Results-We performed proteomics assays among participants from the Framingham Heart Study Offspring ...
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(Journal of the American Heart Association, 2019-08-20)Background-Duchenne muscular dystrophy (DMD) is an X-linked disease that causes progressive muscle weakness. Affected boys typically die from respiratory or cardiac failure. Golden retriever muscular dystrophy (GRMD) is ...
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(Journal of the American Heart Association, 2019-08-20)Background-alpha Carboxyl terminus 1 (alpha CT1) is a 25-amino acid therapeutic peptide incorporating the zonula occludens-1 (ZO-1)-binding domain of connexin 43 (Cx43) that is currently in phase 3 clinical testing on ...
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(Journal of the American Heart Association, 2019-09-23)Background-Identification of occult diastolic dysfunction often requires invasive right heart catheterization with provocative maneuvers such as fluid challenge. Non-invasive predictors of occult diastolic dysfunction have ...
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(European Journal of Heart Failur, 2019-09)Current pharmacological therapies for heart failure with reduced ejection fraction are largely either repurposed anti-hypertensives that blunt overactivation of the neurohormonal system or diuretics that decrease congestion. ...