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Predictive Effects of Quality and Duration of Sleep on Cognition and CSF Biomarkers

dc.contributor.advisorJefferson, Angela Lee
dc.contributor.authorCalabro, Alexandria
dc.descriptionThis study examined whether sleep quality or sleep duration was a better predictor of cognition and CSF biomarker levels in older adults with normal cognition and MCI. Course PSY 4998, Honors Thesis, Professor Jo-Anne Bachorowski.en_US
dc.description.abstractCurrent literature on the effects of sleep on cognition has shown conflicting results regarding the effects of long and short sleep duration. Using previously collected data from the Vanderbilt Memory & Aging Project, this study explored the association between sleep and cognitive functioning and cerebrospinal fluid biomarker components of Alzheimer’s disease pathophysiology in older adults with normal cognition and mild cognitive impairment. Sleep quality was hypothesized to be a better predictor of cognitive functioning and cerebrospinal fluid biomarkers. The sample consisted of 66 older adults, with a mean age of 73.29. Half of the sample had mild cognitive impairment, while the other half had normal cognition. Results showed no significant predictive effects of either sleep quality or sleep duration on either cognitive measures or cerebrospinal fluid biomarker levels. However, results did show some sleep quality x diagnosis interaction effects for information processing speed, executive function and amyloid-beta levels, and sleep quality x sleep duration interaction for global cognition and amyloid-beta levels.en_US
dc.description.sponsorshipThesis completed in partial fulfillment of the requirements of the Honors Program in Psychological Sciences under the direction of Dr. Angela Jefferson, Ph.D.en_US
dc.publisherVanderbilt Universityen_US
dc.subjectAlzheimer's diseaseen_US
dc.subjectmild cognitive impairmenten_US
dc.subject.lcshBiochemical markersen_US
dc.subject.lcshSleep -- Physiological aspectsen_US
dc.subject.lcshMild cognitive impairmenten_US
dc.subject.lcshAmyloid beta-proteinen_US
dc.titlePredictive Effects of Quality and Duration of Sleep on Cognition and CSF Biomarkersen_US
dc.description.collegeCollege of Arts and Scienceen_US
dc.description.schoolVanderbilt Universityen_US

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