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Effects of Dopamine on Reward Learning in Parkinson’s Patients with Impulse Control Disorders

dc.contributor.advisorZald, David H.
dc.contributor.authorQualls, Lydia
dc.description.abstractThis study investigated how dopamine agonist medication differentially affects reward learning in Parkinson’s patients with and without Impulse Control Disorders (ICDs). We tested 16 patients (8 female, 5 with ICDs, mean age = 62.1) on and off of their dopamine agonist medication using a dynamic foraging task with probability reversals. We hypothesized that patients with ICDs, but not patients without ICDs, would have worse task performance on medication than off medication. Paired samples t-tests confirmed our hypothesis – that task performance was significantly worse on medication than off for ICD patients [t(4) = 2.86, p = .046], but not for non-ICD patients [t(10) = 1.67, p = .126]. This suggests that ICD patients are more vulnerable to medication effects that cause aberrant reward learning, which could be the basis of their impulse control behaviors.en_US
dc.description.sponsorshipThesis completed in partial fulfillment of the requirements of the Honors Program in Psychological Sciences under the advisement of Dr. David Zald.en_US
dc.publisherVanderbilt Universityen_US
dc.subjectParkinson's Diseaseen_US
dc.subjectImpulse Control Disordersen_US
dc.subjectReward Learningen_US
dc.subjectCrab Tasken_US
dc.subject.lcshCognitive psychologyen_US
dc.subject.lcshImpulse control disordersen_US
dc.subject.lcshParkinson's diseaseen_US
dc.subject.lcshDopamine -- Agonistsen_US
dc.subject.lcshReward (Psychology)en_US
dc.titleEffects of Dopamine on Reward Learning in Parkinson’s Patients with Impulse Control Disordersen_US
dc.title.alternativeDopamine and learning in ICD patientsen_US
dc.description.collegeArts & Sciencesen_US
dc.description.schoolVanderbilt Universityen_US

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