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Investigating Brain Networks in Anxious-Misery and Fear Symptom Dimensions

dc.contributor.authorPines, Julia
dc.descriptionThis paper was written in PSY 4999 Honors Thesis class as part of Dr. Antonia Kaczkurkin's Brains Lab.en_US
dc.description.abstractAnxiety and depressive symptoms can be dissociated into anxious-misery and fear components; however, little is known about how these two symptom dimensions differ in terms of brain network properties. Thus, the purpose of this study was to compare the local efficiency of the default mode network (DMN) and frontoparietal network (FPN) in anxious-misery and fear symptom dimensions, with examination of six additional networks and small-worldness as exploratory analyses. To do this, we used data from children ages 9-10 years old from the Adolescent Brain Cognitive Development (ABCD) Study database. Our primary measure of interest was local efficiency, which measures the efficiency of information exchange between nodes of a network when one node is removed. We hypothesized that the DMN would exhibit increased local efficiency and the FPN would show decreased local efficiency in anxious-misery symptoms, and both networks would have lower local efficiency in fear symptoms. We found no significant associations between local efficiency and anxious-misery and fear dimensions or between small-world omega and the dimensions. However, we found a significant positive association between anxious-misery symptoms and local efficiency in the FPN and a significant negative association between fear symptoms and local efficiency in the FPN at uncorrected levels. These results suggest the need for further study of local efficiency in the FPN in an older population and the use of other network metrics in anxious-misery and fear symptom dimensions.en_US
dc.description.sponsorshipThesis completed in partial fulfillment of the requirements of the Honors Program in Psychological Sciencesen_US
dc.publisherVanderbilt Universityen_US
dc.subjectBrain networken_US
dc.subjectLocal efficiencyen_US
dc.titleInvestigating Brain Networks in Anxious-Misery and Fear Symptom Dimensionsen_US

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