Browsing by Department "Biochemistry"
Now showing items 1-20 of 125
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(2021-02-12)Department: BiochemistryHuman cells are constantly exposed to endogenous and exogenous sources of DNA damage that cause thousands of DNA lesions in each cell every day. Accurate repair of these lesions ensures maintenance of genome stability and ...
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(2019-11-15)Department: BiochemistryMyo-Inositol is the precursor to a family of molecules called inositides. The two major classes of inositides, the lipid phosphatidylinositol phosphates (PIPs) and the water-soluble inositol phosphates (IPs) are conserved ...
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(2007-10-03)Department: BiochemistryThe ErbB family of receptor tyrosine kinases regulates cell growth, differentiation, and tumorigenesis. This dissertation contains two independent studies of ErbB-1 and ErbB-4. In one study, the intracellular juxtamembrane ...
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Analyzing genome integrity during DNA replication using iPOND (isolation of Proteins On Nascent DNA) (2013-07-12)Department: BiochemistryThe in vivo analysis of dynamic events that protect genomic and epigenomic integrity during DNA replication has been a challenging task. The proteins that ensure the accurate inheritance of the genome act directly at ...
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(2020-06-02)Department: BiochemistryAbasic (AP) sites are one of the most common DNA lesions that can block replicative polymerases. Currently, all known mechanisms for AP site repair function within the context of double-stranded DNA (dsDNA). A newly ...
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(2022-08-02)Department: BiochemistryAquaporin-5 (AQP5) regulates osmotic balance and transparency of the ocular lens through facilitated diffusion of water and represents an integral component of the lens microcirculation system, which convects nutrients to ...
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(2023-07-18)Department: BiochemistryNonvisual arrestins (arrestin-2 and arrestin-3) regulate a wide range of signaling events, most notably when bound to active G protein-coupled receptors (GPCRs). Among the known effectors recruited by GPCR-bound arrestins ...
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(2023-07-18)Department: BiochemistryNonvisual arrestins (arrestin-2 and arrestin-3) regulate a wide range of signaling events, most notably when bound to active G protein-coupled receptors (GPCRs). Among the known effectors recruited by GPCR-bound arrestins ...
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(2011-12-09)Department: BiochemistryBIOCHEMISTRY ASSESSING THE COMPONENTS OF THE eIF3 COMPLEX AND THEIR PHOSPHORYLATION STATUS ADAM RICHARD FARLEY Dissertation under the direction of Professor Andrew J. Link The eukaryotic initiation factor 3 (eIF3) is ...
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(2023-03-14)Department: BiochemistryType II topoisomerases are essential enzymes that regulate the topological state of DNA. These enzymes function by performing a double-stranded DNA passage reaction, the process of which generates a covalent enzyme-cleaved ...
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(2010-10-29)Department: BiochemistryThe mechanism controlling the switch between gene activation and repression is critically important for understanding the process of transcriptional regulation. Gene expression is highly controlled through a dynamic exchange ...
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(2012-03-28)Department: BiochemistrySimian Virus 40 uses its Large T antigen protein to bind and inactivate retinoblastoma tumor suppressor proteins, yielding cell transformation. T antigen is a modular protein with four domains connected by linkers. The ...
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(2008-07-28)Department: BiochemistryThe replication of DNA occurs through a complex series of steps involving the coordinated action of many proteins. DNA polymerase alpha/primase (pol-prim) is a critical DNA replication factor that synthesizes short RNA-DNA ...
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(2013-12-03)Department: BiochemistryEngineered biocatalysts have become increasingly sought after as replacements for individual chemical synthetic steps. However, their implementation in multistep sequences as biosynthetic pathways has proven to be a ...
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(2024-03-22)Department: BiochemistryGenome integrity is established through the high fidelity and efficient replication of cellular DNA as well as the ability to repair DNA when DNA damage or errors occur. A wide array of genotoxins can interfere with DNA ...
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Characterization of SRAP Domain DNA-Protein Crosslink Formation and Reversal with DNA Abasic Sites (2022-06-27)Department: BiochemistryApuirinic/apyrimidinic (AP, or abasic) sites in DNA are one of the most common forms of DNA damage. AP sites are reactive and form crosslinks to both proteins and DNA, are prone to strand breakage, and inhibit DNA replication ...
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(2016-03-29)Department: BiochemistryBIOCHEMISTRY Comparative Biochemical and Structural Analysis of the Alzheimer’s Disease Related Proteins: Amyloid Precursor Protein and Notch 1. Catherine Laura Deatherage Dissertation under the direction of Professor ...
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(2023-12-12)Department: BiochemistryDNA replication and transcription occur in all living cells across all domains of life. Both essential processes occur simultaneously, on the same template, leading to conflicts between their macromolecular machines. Head-on ...
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(2022-03-21)Department: BiochemistryType II topoisomerases are necessary enzymes that regulate the topological state of DNA by creating transient double-stranded breaks. Topoisomerase II poisons act by stabilizing the covalent enzyme-cleaved DNA complex, ...
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(2008-12-03)Department: BiochemistryMolecular events involved in successful embryo implantation take place in defined time and space but are not generally well understood. Here for the first time, we use MALDI Imaging Mass Spectrometry (IMS) technologies ...