Browsing by Title
Now showing items 6709-6728 of 17424
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(2019-12-09)Department: BiochemistryTriple-negative breast cancer (TNBC) is an aggressive form of breast cancer that does not respond to endocrine therapy or human epidermal growth factor receptor 2 (HER2)-targeted therapies. Individuals with TNBC experience ...
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(2016-04-04)Department: Cancer BiologySalivary adenoid cystic carcinoma (ACC) is prone to perineural invasion, late recurrence, and distal metastases, with 20-year survival of only 10%. Research defining new targets in ACC has lagged largely due to a dearth ...
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(2016-03-01)Department: PharmacologyAcetylcholine controls or modulates virtually every physiological process from the regulation of skeletal and smooth muscle contraction, to learning and memory (Sellers & Chess-Williams, 2012). Consequently, alterations ...
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(2010-06-16)Department: BiochemistryAfter 30 years of research, p53 is recognized as one of the most frequently mutated genes in human cancer (Baker et al, 1989; Nigro et al, 1989; Momand et al, 2000; Daujat et la, 2001). To accomplish its tumor suppressive ...
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(Vanderbilt University, 2001)When data contain errors, parameters of interest typically are not identified without imposing strong assumptions. However, in many cases, bounds on these parameters can be constructed under relatively weak assumptions. ...
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(2021-11-19)Department: Biomedical InformaticsClinical prediction models are increasingly common, particularly with advances in machine learning. Assigning outcome labels on which to train these models is challenging due to the time-consuming and resource-intensive ...
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(2006-12-07)Department: BiochemistryBIOCHEMISTRY IDENTIFICATION AND REGULATION OF P53 TARGET GENES IN PRIMARY HUMAN EPIDERMAL KERATINOCYTES KRISTY L. SCHAVOLT Dissertation under the direction of Professor Jennifer A. Pietenpol The p53 tumor suppressor ...
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Identification and Scoring of Partial Covalent Interactions in Proteins and Protein Ligand Complexes (2013-12-16)Department: ChemistryPartial covalent interactions (PCI) such as hydrogen bonds, salt bridges, cation-π, and π-π interactions contribute to protein thermostability. Algorithms that identify PCIs rely on pairwise atom-atom angles and distances, ...
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(Intensive Care Medicine, 2020-02)Purpose The aim of the RUBY study was to evaluate novel candidate biomarkers to enable prediction of persistence of renal dysfunction as well as further understand potential mechanisms of kidney tissue damage and repair ...
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(NATURE COMMUNICATIONS, 2019-07-09)Fibrosis accompanying wound healing can drive the failure of many different organs. Activated fibroblasts are the principal determinants of post-injury pathological fibrosis along with physiological repair, making them a ...
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(2017-04-04)Department: Cell and Developmental BiologyApico-basolateral polarity is a fundamental property of epithelial cells, and its loss is a hallmark of colorectal cancer (CRC). Role(s) for lateral integrins in this polarization process and the consequences of their ...
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(2005-07-18)Department: Cell and Development BiologyFertilization is a complex process involving several steps, including sperm activation, oocyte maturation, chemotaxis, gamete recognition, and cell fusion. Many of these essential steps are controlled and regulated by ...
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(2010-08-04)Department: Interdisciplinary Studies: Applied StatisticsMultiple sclerosis (MS) is characterized as an autoimmune neurodegenerative disease. The disease manifests as demyelination or degradation of the myelin sheath in the central nervous system. The Major Histocompatibility ...
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(2008-08-04)Department: Molecular Physiology and BiophysicsBone morphogenetic protein 4 (Bmp4) is a multi-functional, developmentally regulated gene and is essential for early mouse development. Little is known about the transcriptional regulation of Bmp4. To investigate the ...
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(2021-05-13)Department: Cell & Developmental BiologyThe body of work presented in this dissertation details the characterization of a novel human-cell derived model of the understudied, non-canonical cullin scaffold CUL9. Unlike other cullins, previous efforts to characterize ...
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(Nature Communications, 2019-08-08)Drug hypersensitivity such as severe cutaneous adverse reactions (SCAR), including Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), could be life-threatening. Here, we enroll SCAR patients to investigate ...
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(2013-11-25)Department: NeuroscienceEpilepsy is a neurological disorder affecting approximately 3 million Americans. Two-thirds of patients diagnosed with epilepsy have no known cause for their disease, however recent evidence suggests most result from complex ...
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(2016-03-30)Department: BiochemistryClostridium difficile is the leading cause of hospital-acquired diarrhea in the United States. The two main virulence factors of C. difficile are the large toxins, TcdA and TcdB, which enter colonic epithelial cells and ...
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(2023-08-14)Department: Molecular Physiology & BiophysicsThis thesis identifies the molecular and physiological targets downstream of glucagon-like peptide-1 receptor (GLP-1R) activation that promote the weight-lowering effect of GLP-1R agonists. The first project builds on ...
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(2009-02-10)Department: Microbiology and ImmunologyUncoating of the viral core following penetration into the target cell represents a fundamentally obscure step in the HIV-1 life cycle. Our laboratory has previously reported that mutations in the CA protein that positively ...