Muscarinic acetylcholine receptors (mAChRs), specifically M1 and M4 subtypes, provide viable targets for the treatment of multiple central nervous system disorders. However, highly selective activators of either M1 or M4 ...

The focus of this work was to establish quantitative structure activity (QSAR, potency of allosteric modulators) and property (QSPR, carbon chemical shifts) relations for molecules with known structure and activity/property ...

In an engineered composite material, the behavior of different phases and their interactions determine the response of the material as a whole. Data-driven machine learning techniques have emerged as a promising tool for ...

Autism Spectrum Disorder (ASD) is a neuro-developmental disorder with a high prevalence rate of 1 in 68 children in the U.S. Human-Machine Interaction (HMI) is being continuously explored as a potential efficacious ...

Drawing on the recent financial crisis, we introduce the concept of macro-risk. We distinguish between micro-risks, which can be managed within conventional economic frameworks, and macro-risks, which threaten to disrupt ...

This study examines the comic vision of Miguel de Cervantes as manifested in his masterpiece, Don Quixote de la Mancha. Employing theories stemming principally from Mikhail Bakhtin and Michel Foucault, I look at how Cervantes ...

This dissertation examines the representation of magical objects in Victorian literature. The Victorian period is often characterized as a time of increased secularity. Scientists, sociologists, and anthropologists in the ...

Magnetic actuation is currently the most promising approach for actively and wirelessly manipulating capsule endoscopes (CEs) inside the gastrointestinal (GI) tract. Actively actuated CEs have the potential to transform ...