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Pyridoxamine protects against glucose-induced protein damage
(2006-04-12)
Non-enzymatic modification by glucose of proteins induces protein damage through the formation of advanced glycation end products (AGEs). AGEs have been implicated in the pathogenesis of a number of diseases including ...
Identification of protein markers of drug-induced nephrotoxicity by MALDI MS: in vivo discovery of ubiquitin-t
(2009-04-09)
This study demonstrated the utility of direct tissue MALDI MS in identifying early markers of antibiotic induced nephrotoxicity. Using a histology directed approach, twelve proteins were identified as having statistically ...
Replication dependent mechanisms of genome maintenance
(2009-04-10)
The DNA Damage Response (DDR) is an inducible barrier to tumorigenesis at its earliest stages of development. Evidence from cell culture, animal models, and clinical samples reveals DDR activation in response to activation ...
Structural characterization of the receptor for advanced glycation end products reveals a two domain modular architecture
(2007-05-30)
The Receptor for Advanced Glycation End Products (RAGE) contains a single transmembrane helix, a small cytosolic domain, and an extracellular region (sRAGE) composed of three Ig-like domains (V, C1, C2). RAGE has been ...