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Temporal changes in ART initiation in adults with high CD4 counts in Latin America: a cohort study
(Journal of the International AIDS Society, 2019-12)
Introduction In 2013, the World Health Organization (WHO) recommended initiating combination ART (cART) in all adults with HIV and CD4+ lymphocyte counts (CD4) <500 cells/mm(3). In 2015, this was updated to recommend cART ...
Expanding Hepatitis C Virus Care and Cure: National Experience Using a Clinical Pharmacist-Driven Model
(Open Forum Infectious Diseases, 2019-07)
Background. The US National Viral Hepatitis Action Plan depends on additional providers to expand hepatitis C virus (HCV) treatment capacity in order to achieve elimination goals. Clinical pharmacists manage treatment and ...
Age-Related Differences in Hospitalization Rates, Clinical Presentation, and Outcomes Among Older Adults Hospitalized With Influenza-US Influenza Hospitalization Surveillance Network (FluSurv-NET)
(2019-07)
Background. Rates of influenza hospitalizations differ by age, but few data are available regarding differences in laboratory-confirmed rates among adults aged >= 65 years.
Methods. We evaluated age-related differences ...
Atypical Clinical Manifestations of Loiasis and Their Relevance for Endemic Populations
(Open Forum Infectious Diseases, 2019-11)
Background. Loiasis is mostly considered a relatively benign infection when compared with other filarial and parasitic diseases, with Calabar swellings and eyeworm being the most common signs. Yet, there are numerous reports ...
Host Inflammatory Biomarkers of Disease Severity in Pediatric Community-Acquired Pneumonia: A Systematic Review and Meta-analysis
(Open Forum Infectiouis Diseases, 2019-12)
Background. Community-acquired pneumonia (CAP) is the leading cause of death in children. Identification of reliable bio-markers offers the potential to develop a severity quantitative score to assist in clinical decision-making ...
Combination immunotherapy and radiotherapy causes an abscopal treatment response in a mouse model of castration resistant prostate cancer
(Journal for Immunotherapy of Cancer, 2019-08-14)
Background Prostate cancer is poorly responsive to immune checkpoint inhibition, yet a combination with radiotherapy may enhance the immune response. In this study, we combined radiotherapy with immune checkpoint inhibition ...