• Longitudinal Antibody Responses in People Who Inject Drugs Infected With Similar Human Immunodeficiency Virus Strains 

  Georgiev, Ivelin S. (Journal of Infectious Diseases, 2020-03-01)

  Background. Multiple factors influence the human immunodeficiency virus (HIV) antibody response produced during natural infection, leading to responses that can vary in specificity, strength, and breadth. Methods. People ...
• TSLP and IL-33 reciprocally promote each other's lung protein expression and ILC2 receptor expression to enhance innate type-2 airway inflammation 

  Toki, Shinji; Goleniewska, Kasia; Zhang, Jian; Zhou, Weisong; Newcomb, Dawn C.; Zhou, Baohua; Kita, Hirohito; Boyd, Kelli L.; Peebles, Ray S., Jr. (Allergy, 2020-02)

  Background The epithelial cell-derived danger signal mediators thymic stromal lymphopoietin (TSLP) and IL-33 are consistently associated with adaptive Th2 immune responses in asthma. In addition, TSLP and IL-33 synergistically ...
• The Anti-Proliferative and Anti-Invasive Effect of Leaf Extracts of Blueberry Plants Treated with Methyl Jasmonate on Human Gastric Cancer In Vitro Is Related to Their Antioxidant Properties 

  Ribera-Fonseca, Alejandra; Jimenez, Danae; Leal, Pamela; Riquelme, Ismael; Carlos Roa, Juan; Alberdi, Miren; Peek, Richard M.; Reyes-Diaz, Marjorie (Antioxidants, 2020-01)

  Gastric cancer is the third main cause of cancerous tumors in humans in Chile. It is well-accepted that a diet rich in antioxidant plants could help in fighting cancer. Blueberry is a fruit crop with a high content of ...
• Atypical Clinical Manifestations of Loiasis and Their Relevance for Endemic Populations 

  Buell, Kevin G.; Whittaker, Charles; Chesnais, Cedric B.; Jewell, Paul D.; Pion, Sebastien D. S.; Walker, Martin; Basanez, Maria-Gloria; Boussinesq, Michel (Open Forum Infectious Diseases, 2019-11)

  Background. Loiasis is mostly considered a relatively benign infection when compared with other filarial and parasitic diseases, with Calabar swellings and eyeworm being the most common signs. Yet, there are numerous reports ...
• Host Inflammatory Biomarkers of Disease Severity in Pediatric Community-Acquired Pneumonia: A Systematic Review and Meta-analysis 

  Fernandes, Catarina D.; Arriaga, Maria B.; Costa, Maria Carolina M.; Costa, Maria Clara M.; Costa, Maria Heloina M.; Vinhaes, Caian L.; Silveira-Mattos, Paulo S.; Fukutani, Kiyoshi F.; Andrade, Bruno B. (Open Forum Infectiouis Diseases, 2019-12)

  Background. Community-acquired pneumonia (CAP) is the leading cause of death in children. Identification of reliable bio-markers offers the potential to develop a severity quantitative score to assist in clinical decision-making ...
• Expanding Hepatitis C Virus Care and Cure: National Experience Using a Clinical Pharmacist-Driven Model 

  Koren, David E.; Zuckerman, Autumn; Teply, Robyn; Nabulsi, Nadia A.; Lee, Todd A.; Martin, Michelle T. (Open Forum Infectious Diseases, 2019-07)

  Background. The US National Viral Hepatitis Action Plan depends on additional providers to expand hepatitis C virus (HCV) treatment capacity in order to achieve elimination goals. Clinical pharmacists manage treatment and ...
• Age-Related Differences in Hospitalization Rates, Clinical Presentation, and Outcomes Among Older Adults Hospitalized With Influenza-US Influenza Hospitalization Surveillance Network (FluSurv-NET) 

  Schaffner, William (2019-07)

  Background. Rates of influenza hospitalizations differ by age, but few data are available regarding differences in laboratory-confirmed rates among adults aged >= 65 years. Methods. We evaluated age-related differences ...
• Trends in Incidence of Methicillin-resistant Staphylococcus aureus Bloodstream Infections Differ by Strain Type and Healthcare Exposure, United States, 2005-2013 

  Schaffner, William (Clinical Infectiouis Diseases, 2020-01-01)

  Background. Previous reports suggested that US methicillin-resistant Staphylococcus aureus (MRSA) strain epidemiology has changed since the rise of USA300 MRSA. We describe invasive MRSA trends by strain type. Methods. ...
• Directly observed therapy and risk of unfavourable tuberculosis treatment outcomes among an international cohort of people living with HIV in low- and middle-income countries 

  Pettit, April C.; Jenkins, Cathy A.; Peratikos, Meridith Blevins; Yotebieng, Marcel; Diero, Lameck; Do, Cuong D.; Ross, Jeremy; Veloso, Valdilea G.; Hawerlander, Denise; Marcy, Olivier; Shepherd, Bryan E.; Fenner, Lukas; Sterling, Timothy R. (Journal of the International AIDS Society, 2019-12)

  Introduction Identification of persons living with human immunodeficiency virus (HIV)-associated tuberculosis (TB) at increased risk for unfavourable TB outcomes would inform efforts to improve such outcomes. We sought to ...
• Temporal changes in ART initiation in adults with high CD4 counts in Latin America: a cohort study 

  Rebeiro, Peter F. (Journal of the International AIDS Society, 2019-12)

  Introduction In 2013, the World Health Organization (WHO) recommended initiating combination ART (cART) in all adults with HIV and CD4+ lymphocyte counts (CD4) <500 cells/mm(3). In 2015, this was updated to recommend cART ...
• Determinants of Restoration of CD4 and CD8 Cell Counts and Their Ratio in HIV-1-Positive Individuals With Sustained Virological Suppression on Antiretroviral Therapy 

  Sterling, Timothy R.; Sterling, Tim (JAIDS- Journal of Acquired Immune Deficiency Syndromes, 2019-03-01)

  Background: An increasing number of HIV-positive individuals now start antiretroviral therapy (ART) with high CD4 cell counts. We investigated whether this makes restoration of CD4 and CD8 cell counts and the CD4: CD8 ratio ...
• Combination immunotherapy and radiotherapy causes an abscopal treatment response in a mouse model of castration resistant prostate cancer 

  Dudzinski, Stephanie O.; Cameron, Brent D.; Wang, Jian; Rathmell, Jeffrey C.; Giorgio, Todd D.; Kirschner, Austin N. (Journal for Immunotherapy of Cancer, 2019-08-14)

  Background Prostate cancer is poorly responsive to immune checkpoint inhibition, yet a combination with radiotherapy may enhance the immune response. In this study, we combined radiotherapy with immune checkpoint inhibition ...
• Human papillomavirus vaccination completion rates among gynecological providers: an institutional retrospective review 

  Elsamadicy, Emad A.; Schneiter, Mali K.; Hull, Pamela C.; Khabele, Dineo (Human Vaccines & Immunotherapeutics, 2019-08-03)

  Objective: The primary aim of this study is to assess and characterize correlates of human papillomavirus (HPV) vaccine series completion among young adult women evaluated by gynecological (GYN) providers at a single ...
• Urinary Metabolomics Validates Metabolic Differentiation Between Renal Cell Carcinoma Stages and Reveals a Unique Metabolic Profile for Oncocytomas 

  Falegan, Oluyemi S.; Egloff, Shanna A. Arnold; Zijlstra, Andries; Hyndman, M. Eric; Vogel, Hans J. (Metabolites, 2019-08)

  Renal cell carcinoma (RCC) is a heterogeneous malignancy which often develops and progresses asymptomatically. Benign oncocytomas are morphologically similar to malignant chromophobe RCC and distinguishing between these ...
• Phylosymbiosis Impacts Adaptive Traits in Nasonia Wasps 

  van Opstal, Edward J.; Bordenstein, Seth R. (MBIO, 2019-07)

  Phylosymbiosis is defined as microbial community relationships that recapitulate the phylogeny of hosts. As evidence for phylosymbiosis rapidly accumulates in different vertebrate and invertebrate holobionts, a central ...
• CD8(+) T Lymphocyte and NK Cell Network: Circuitry in the Cytotoxic Domain of Immunity 

  Uzhachenko, Roman, V.; Shanker, Anil (Frontiers in Immunology, 2019-08-13)

  Multiple effector layers in the immune system ensure an optimal temporal and spatial distribution of immune defense. Cytotoxic innate lymphoid natural killers (NK) and adaptive CD8(+) T lymphocytes (CTL) interact to elicit ...
• Obesity and Fat Metabolism in Human Immunodeficiency Virus-Infected Individuals: Immunopathogenic Mechanisms and Clinical Implications 

  Godfrey, Catherine; Bremer, Andrew; Alba, Diana; Apovian, Caroline; Koethe, John R.; Koliwad, Suneil; Lewis, Dorothy; Lo, Janet; McComsey, Grace A.; Eckard, Allison; Srinivasa, Suman; Trevillyan, Janine; Palmer, Clovis; Grinspoon, Steven (The Journal of Infectious Diseases, 2019-08-01)

  Metabolic complications relating to complex effects of viral and immune-mediated mechanisms are now a focus of clinical care among persons living with human immunodeficiency virus (PLHIV), and obesity is emerging as a ...
• lBromodomain inhibitor JQ1 reversibly blocks IFN-gamma production 

  Gibbons, Hunter R.; Mi, Deborah J.; Farley, Virginia M.; Esmond, Tashawna; Kaood, Mary B.; Aune, Thomas M. (Scientific Reports, 2019-07-16)

  As a class, 'BET' inhibitors disrupt binding of bromodomain and extra-terminal motif (BET) proteins, BRD2, BRD3, BRD4 and BRDT, to acetylated histones preventing recruitment of RNA polymerase 2 to enhancers and promoters, ...
• Epigenetic Aspects of Engineered Nanomaterials: Is the Collateral Damage Inevitable? 

  Gedda, Mallikarjuna Rao; Babele, Piyoosh Kumar; Zahra, Kulsoom; Madhukar, Prasoon (Frontiers in Bioengineering and Biotechnology, 2019-09-20)

  The extensive application of engineered nanomaterial (ENM) in various fields increases the possibilities of human exposure, thus imposing a huge risk of nanotoxicity. Hence, there is an urgent need for a detailed risk ...
• Fluctuations of Spleen Cytokine and Blood Lactate, Importance of Cellular Immunity in Host Defense Against Blood Stage Malaria Plasmodium yoelii 

  Imai, Takashi; Suzue, Kazutomo; Ngo-Thanh, Ha; Ono, Suguri; Orita, Wakako; Suzuki, Haruka; Shimokawa, Chikako; Olia, Alex; Obi, Seiji; Taniguchi, Tomoyo; Ishida, Hidekazu; Van Kaer, Luc; Murata, Shigeo; Tanaka, Keiji; Hisaeda, Hajime (Frontiers in Immunology, 2019-09-25)

  Our previous studies of protective immunity and pathology against blood stage malaria parasites have shown that not only CD4(+) T cells, but also CD8(+) T cells and macrophages, are important for host defense against blood ...

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