Browsing Cell & Developmental Biology by Title

Now showing items 15-17 of 17

    • Structural state recognition facilitates tip tracking of EB1 at growing microtubule ends 
      Reid, Taylor A.; Coombes, Courtney; Mukherjee, Soumya; Goldblum, Rebecca R.; White, Kyle; Parmar, Sneha; McClellan, Mark; Zanic, Marija; Courtemanche, Naomi; Gardner, Melissa K. (eLIFE, 2019-09-03)
      The microtubule binding protein EB1 specifically targets the growing ends of microtubules in cells, where EB1 facilitates the interactions of cellular proteins with microtubule plus-ends. Microtubule end targeting of EB1 ...
    • Targeting WDR5: A WINning Anti-Cancer Strategy? 
      Aho, Erin R.; Weissmiller, April M.; Fesik, Stephen W.; Tansey, William P. (EPIGENETICS INSIGHTS, 2019-07-18)
      WDR5 is a component of multiple epigenetic regulatory complexes, including the mixed lineage leukemia (MLL)/SET complexes that deposit histone H3 lysine 4 methylation. Inhibitors of an arginine-binding cavity in WDR5, known ...
    • USP9X Deubiquitylates DVL2 to Regulate WNT Pathway Specification 
      Nielsen, Casey P.; Jemigan, Kristin K.; Diggins, Nicole L.; Webb, Donna J.; MacGurn, Jason A. (Cell Reports, 2019-07-23)
      The WNT signaling network is comprised of multiple receptors that relay various input signals via distinct transduction pathways to execute multiple complex and context-specific output processes. Integrity of the WNT ...