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Mapping eGFR loci to the renal transcriptome and phenome in the VA Million Veteran Program

Hellwege, Jacklyn N; Edwards, Digna R. Velez; Giri, Ayush; Torstenson, Eric S.; Keaton, Jacob M.; Chung, Cecilia P.; Edwards, Todd L.; Hung, Adriana M.; Roumie, Christianne L.; Siew, Edward (Nature Communications, 2019-08-26)

Chronic kidney disease (CKD), defined by low estimated glomerular filtration rate (eGFR), contributes to global morbidity and mortality. Here we conduct a transethnic Genome-Wide Association Study of eGFR in 280,722 ...

Peroxidasin Is a Novel Target of Autoantibodies in Lupus Nephritis

Manral, Pallavi; Colon, Selene; Bhave, Gautam; Zhao, Ming-Hui; Jain, Sanjay; Borza, Dorin-Bogdan (Kidiney International Reports, 2019-07)

APOL1, Acid Load, and CKD Progression

Pike, Mindy; Stewart, Thomas G.; Morse, Jennifer; Ormsby, Patrick; Siew, Edward D.; Hung, Adriana; Abdel-Kader, Khaled; Ikizler, T. Alp; Lipworth, Loren; Robinson-Cohen, Cassianne (Kidney International Reports, 2019-07)

Introduction: High dietary acid load and metabolic acidosis are associated with an accelerated decline in kidney function and may contribute to the observed heterogeneity in end-stage renal disease (ESRD) risk according ...

WNK4 limits distal calcium losses following acute furosemide treatment

Ferdaus, Mohammed Z.; Gratreak, Brittany D. K.; Miller, Lauren; Si, Jinge; McCormick, James A.; Yang, Chao-Ling; Ellison, David H.; Terker, Andrew S. (Physiological Reports, 2019-09)

The distal nephron is essential for calcium homeostasis. This is evidenced by disordered calcium transport following disrupted distal nephron function occurring in salt-wasting tubulopathies or with diuretic use. A plethora ...

Cardiovascular disease in the kidney transplant recipient: epidemiology, diagnosis and management strategies

Birdwell, Kelly A.; Rangaswami, Janani; Mathew, Roy O.; Parasuraman, Raviprasenna; Tantisattamo, Ekamol (NEPHROLOGY DIALYSIS TRANSPLANTATION, 2019-05)

Kidney transplantation (KT) is the optimal therapy for end-stage kidney disease (ESKD), resulting in significant improvement in survival as well as quality of life when compared with maintenance dialysis. The burden of ...

Racial disparities in end-stage renal disease in a high-risk population_the Southern Community Cohort Study

Bock, Fabian; Stewart, Thomas G.; Robinson-Cohen, Cassianne; Morse, Jennifer; Kabagambe, Edmond K.; Cavanaugh, Kerri L.; Birdwell, Kelly A.; Hung, Adriana M.; Abdel-Kader, Khaled; Siew, Edward D.; Akwo, Elvis A.; Blot, William J.; Ikizler, T. Alp; Lipworth, Loren (BMC Nephrology, 2019-08-07)

Introduction The Southern Community Cohort Study is a prospective study of low socioeconomic status (SES) blacks and whites from the southeastern US, where the burden of end-stage renal disease (ESRD) and its risk factors ...

Use of a Decision Aid for Patients Considering Peritoneal Dialysis and In-Center Hemodialysis: A Randomized Controlled Trial

Subramanian, Lalita; Zhao, Junhui; Zee, Jarcy; Knaus, Megan; Fagerlin, Angela; Perry, Erica; Swartz, June; McCall, Margie; Bryant, Nicole; Tentori, Francesca (American Journal of Kidney Diseases, 2019-09)

Rationale & Objective: Annually, about 100,000 US patients face the difficult choice between the most common dialysis types, in-center hemodialysis and peritoneal dialysis. This study evaluated the value of a new decision ...