Now showing items 1-7 of 7
Mapping eGFR loci to the renal transcriptome and phenome in the VA Million Veteran Program
(Nature Communications, 2019-08-26)
Chronic kidney disease (CKD), defined by low estimated glomerular filtration rate (eGFR), contributes to global morbidity and mortality. Here we conduct a transethnic Genome-Wide Association Study of eGFR in 280,722 ...
Peroxidasin Is a Novel Target of Autoantibodies in Lupus Nephritis
(Kidiney International Reports, 2019-07)
APOL1, Acid Load, and CKD Progression
(Kidney International Reports, 2019-07)
Introduction: High dietary acid load and metabolic acidosis are associated with an accelerated decline in kidney function and may contribute to the observed heterogeneity in end-stage renal disease (ESRD) risk according ...
WNK4 limits distal calcium losses following acute furosemide treatment
(Physiological Reports, 2019-09)
The distal nephron is essential for calcium homeostasis. This is evidenced by disordered calcium transport following disrupted distal nephron function occurring in salt-wasting tubulopathies or with diuretic use. A plethora ...
Cardiovascular disease in the kidney transplant recipient: epidemiology, diagnosis and management strategies
(NEPHROLOGY DIALYSIS TRANSPLANTATION, 2019-05)
Kidney transplantation (KT) is the optimal therapy for end-stage kidney disease (ESKD), resulting in significant improvement in survival as well as quality of life when compared with maintenance dialysis. The burden of ...
Racial disparities in end-stage renal disease in a high-risk population_the Southern Community Cohort Study
(BMC Nephrology, 2019-08-07)
Introduction The Southern Community Cohort Study is a prospective study of low socioeconomic status (SES) blacks and whites from the southeastern US, where the burden of end-stage renal disease (ESRD) and its risk factors ...
Use of a Decision Aid for Patients Considering Peritoneal Dialysis and In-Center Hemodialysis: A Randomized Controlled Trial
(American Journal of Kidney Diseases, 2019-09)
Rationale & Objective: Annually, about 100,000 US patients face the difficult choice between the most common dialysis types, in-center hemodialysis and peritoneal dialysis. This study evaluated the value of a new decision ...