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Understanding the Role of Smad4 in Intestinal Homeostasis and Tumorigenesis
(2014-07-31)
Colorectal carcinoma is the third leading cause of cancer related mortality within the United States. Over 90% of these deaths can be attributed to distant metastasis. Therefore, understanding the signaling perturbations ...
Composition, Regulation, and Function of Protein Serine/Threonine Phosphatase•Kinase Signaling Modules
(2014-04-14)
The macromolecular assembly of protein serine/threonine phosphatase•kinase complexes mechanistically enhances the speed and fidelity of cell signaling events. These signaling modules allow for acute regulation of substrates ...
A common mechanism of ATR activation by TOPBP1 and ETAA1
(2021-02-12)
Human cells are constantly exposed to endogenous and exogenous sources of DNA damage that cause thousands of DNA lesions in each cell every day. Accurate repair of these lesions ensures maintenance of genome stability and ...