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The role of NF-kB inducing kinase (NIK) in modulating melanoma tumorigenesis
(2011-10-03)
Nuclear factor-êB (NF-êB) inducing kinase (NIK) is a MAP3K that regulates activation of NF-êB. NIK is often over-expressed in tumor cells, including melanoma, but the significance of this in melanoma progression remains ...
A Comprehensive Framework for Systems Immune Monitoring in Patients with Cancer
(2018-03-29)
The immune system is a complex network of cells spread throughout the body, spanning dozens of tissue types and locations. A complete understanding of a systemic immune response, like those required for the regression of ...
Identification of Novel Targets for Therapy in Solid Tumors
(2015-03-06)
Solid tumor treatment paradigms have drastically improved in recent decades through direct targeting of the protein products of somatic, constitutively active “driver” mutations and their effector signaling pathways. Prior ...