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Systems Biology of Mature Human B cells in Health and Illness
(2017-06-19)
B cells play a crucial role in adaptive immunity. They perform a multitude of functions including antibody and cytokine production and antigen presentation. The human adaptive immune response would not function effectively ...
A Comprehensive Framework for Systems Immune Monitoring in Patients with Cancer
(2018-03-29)
The immune system is a complex network of cells spread throughout the body, spanning dozens of tissue types and locations. A complete understanding of a systemic immune response, like those required for the regression of ...
Quantifying Cellular Heterogeneity in Cancer and the Microenvironment
(2016-11-29)
In spite of recent advances in therapy, cancer remains a leading cause of death worldwide. Therapy response is often unpredictable and relapse frequently occurs. In many cases, this therapy resistance is attributed to ...
Harnessing RIG-I in the tumor microenvironment for therapeutic breast cancer treatment
(2019-11-14)
RIG-I is a cytoplasmic RNA helicase expressed in most cells of the body, functioning to sense viral oligonucleotide motifs then activate innate immune responses to combat viral infection. RIG-I expression and activity is ...