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Development, Optimization and Evaluation of Tumor-Specific Nanosponge Drug Delivery Systems as Chemotherapeutics
(2014-12-03)
Current chemotherapeutic treatments for cancer utilize systemic administration of cytotoxic drugs and produce many side effects in healthy tissues, making optimal treatment of cancer hard to achieve. Tumor targeted ...
A Reductionist Study into the Physiology, Pathology, and Pharmacology of the Mitotic Spindle
(2014-11-26)
Mitotic kinesins represent the new age targets of spindle-poisoning chemotherapies. The kinesin-5 Eg5 is one such example, as kinesin-5 inhibitors (K5Is) induce a lethal mitotic arrest from failed spindle assembly. ...
Mechanisms of Cisplatin Resistance in Triple Negative Breast Cancer
(2014-11-26)
Genomic instability and deregulated proliferation are hallmarks of human tumors. Cytotoxic chemotherapeutics, including cisplatin, have been used for over forty years to combat cancers that have deregulated proliferation ...