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Harnessing RIG-I in the tumor microenvironment for therapeutic breast cancer treatment
(2019-11-14)
RIG-I is a cytoplasmic RNA helicase expressed in most cells of the body, functioning to sense viral oligonucleotide motifs then activate innate immune responses to combat viral infection. RIG-I expression and activity is ...
Mechanisms of Cisplatin Resistance in Triple Negative Breast Cancer
(2014-11-26)
Genomic instability and deregulated proliferation are hallmarks of human tumors. Cytotoxic chemotherapeutics, including cisplatin, have been used for over forty years to combat cancers that have deregulated proliferation ...
Use of anthropometric and genetic data to study body fat mass and distribution with cancer risk in European-ancestry populations
(2020-08-18)
General obesity, measured by BMI, have been linked to increased incidence and mortality of certain cancer. However, BMI does not account for body composition and could not differentiate between muscle mass and fat. I ...