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Mathematical Modeling of Heterogeneity and Drug Response in Lung Cancer
(2018-09-24)
Technological advances have led to increasingly powerful and precise quantification of biological systems. These advances create a need for robust mathematical and computational approaches that are able to integrate complex ...
Delineation of a novel Helicobacter pylori receptor, decay-accelerating factor
(2008-03-19)
Gastric adenocarcinoma is the second leading cause of cancer-related death in the world, and infection with Helicobacter pylori is the strongest known risk factor for this malignancy. Adherence of H. pylori to gastric ...
ALCAM Dynamically Regulates Tumor Cell Adhesion Through Differential Proteolysis and a Novel Binding Partner, Tetraspanin CD151
(2018-03-27)
Metastasis persists as a significant unsolved hurdle in cancer treatment, with greater than 90% of cancer-related deaths attributed to metastasis. In order for cells to successfully metastasize, they must dynamically ...
p120-catenin and p190RhoGAP regulate cell-cell adhesion by coordinating antagonism between Rac and Rho
(2007-04-06)
Integration of receptor tyrosine kinase, integrin, and cadherin activities is crucial for normal cell growth, motility and adhesion. Here, we describe novel roles for p120 catenin (p120) and p190RhoGAP that coordinate ...
Blood vessel epicardial substance (BVES) and BVES binding partners in intestinal homeostasis and tumorigenesis
(2019-09-19)
Blood vessel epicardial substance (BVES or POPDC1) is a tight junction-associated adhesion molecule that regulates epithelial-mesenchymal transition and is downregulated in colorectal cancer via promoter hypermethylation, ...
The role of NF-kB inducing kinase (NIK) in modulating melanoma tumorigenesis
(2011-10-03)
Nuclear factor-êB (NF-êB) inducing kinase (NIK) is a MAP3K that regulates activation of NF-êB. NIK is often over-expressed in tumor cells, including melanoma, but the significance of this in melanoma progression remains ...
Pro and Anti Tumorigenic Effects of EPHA Receptor Signaling in Breast and Lung Cancer
(2010-04-10)
The Eph family of receptor tyrosine kinases has important roles in multiple aspects of cancer development and progression. Substantial advances have been made in understanding the Eph receptor signalling in the pathways ...
Quantifying Cellular Heterogeneity in Cancer and the Microenvironment
(2016-11-29)
In spite of recent advances in therapy, cancer remains a leading cause of death worldwide. Therapy response is often unpredictable and relapse frequently occurs. In many cases, this therapy resistance is attributed to ...
Harnessing RIG-I in the tumor microenvironment for therapeutic breast cancer treatment
(2019-11-14)
RIG-I is a cytoplasmic RNA helicase expressed in most cells of the body, functioning to sense viral oligonucleotide motifs then activate innate immune responses to combat viral infection. RIG-I expression and activity is ...
The Role of VAPB in Breast Cancer
(2012-12-07)
VAPB (VAMP-associated protein B) is an endoplasmic reticulum protein that regulates multiple biological functions. VAPB protein expression is elevated in human breast cancers and correlates with poor prognosis. Despite ...