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Predicting the Spatio-Temporal Evolution of Tumor Growth and Treatment Response in a Murine Model of Glioma
(2016-03-30)
Glioblastoma is a highly invasive and aggressive brain tumor which accounts for nearly 82% of all gliomas. Patients with glioblastoma typically have a poor prognosis, suffering recurrence 7 to 10 months from the conclusion ...
Optical imaging of cell cycle-driven tumor heterogeneity
(2016-03-30)
Metabolism-driven changes in cell cycle status introduce a high degree of cellular heterogeneity within a tumor, presenting challenges with evasion from drug treatment and increased likelihood of tumor recurrence. Accordingly, ...
Quantitative In Vitro and In Vivo Characterization of Near Infrared Molecular Imaging Agents for Enhanced Disease Detection
(2007-04-13)
The emerging field of molecular imaging (MI) aims to noninvasively, quantitatively and repetitively monitor biological processes in vivo to detect disease, probe its basis, and study relevant biochemical pathways at the ...
Fluorescence Lifetime Imaging of NAD(P)H Distinguishes Pathways of Metabolic Inhibition
(2016-03-28)
Fluorescence lifetime imaging microscopy (FLIM) of the metabolic co-enzyme nicotinamide adenine dinucleotide (NAD(P)H) non-invasively probes metabolic protein-binding dynamics without the need for exogenous dyes. FLIM ...
High resolution ultrasonic vessel imaging and repeatability of blood flow modeling using an ultrasound contrast agent
(2007-12-27)
Cancer is a complex and adaptable disease, and knowledge of the mechanisms that cause its progression is vital to creating and monitoring anti-cancer therapies. As a tumor grows beyond a few mm3, blood vessels are recruited ...
Optimization, Application, and Cross-correlation of DCE-MRI in Small Animal Models of Cancer
(2010-11-19)
With cancer encompassing a range of disease states and phenotypes, assessing treatment efficacy early, accurately, and non-invasively is essential to optimize therapy planning on an individualized basis. This work discusses ...
Development of combined Raman spectroscopy - optical coherence tomography for the detection of skin cancer
(2009-12-23)
Skin cancer is the most common cancer in the United States, with an incidence rate that continues to rise. Fortunately, it can be highly curable if detected at an early stage. Best clinical practices require physicians to ...
Development of Albumin-Hitchhiking siRNA Conjugates for Therapeutic Mcl-1 Silencing in Triple Negative Breast Cancer
(2022-05-16)
Triple negative breast cancer (TNBC) is characterized by a lack of estrogen receptor, progesterone receptor, and HER2. Patients with TNBC therefore cannot benefit from treatment with one of the molecularly targeted therapies ...