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Role of Host Cell Factor-1 in MYC-driven gene expression and tumorigenesis
(2020-12-06)
The oncoprotein transcription factor MYC is a major driver of malignancy and a highly-validated target for development of anti-cancer therapies. It has, however, proven challenging to inhibit MYC directly. Novel strategies ...
Use of anthropometric and genetic data to study body fat mass and distribution with cancer risk in European-ancestry populations
(2020-08-18)
General obesity, measured by BMI, have been linked to increased incidence and mortality of certain cancer. However, BMI does not account for body composition and could not differentiate between muscle mass and fat. I ...
Genome-Wide CRISPR Screen Identifies Noncanonical NF-κB Signaling as a Regulator of Epithelial Homeostasis
(2021-01-06)
Epithelial cells possess intrinsic mechanisms to maintain an appropriate cell density for normal tissue morphogenesis and homeostasis. Defects in such mechanisms likely contribute to hyperplasia and cancer initiation. To ...
A common mechanism of ATR activation by TOPBP1 and ETAA1
(2021-02-12)
Human cells are constantly exposed to endogenous and exogenous sources of DNA damage that cause thousands of DNA lesions in each cell every day. Accurate repair of these lesions ensures maintenance of genome stability and ...
Development of Albumin-Hitchhiking siRNA Conjugates for Therapeutic Mcl-1 Silencing in Triple Negative Breast Cancer
(2022-05-16)
Triple negative breast cancer (TNBC) is characterized by a lack of estrogen receptor, progesterone receptor, and HER2. Patients with TNBC therefore cannot benefit from treatment with one of the molecularly targeted therapies ...
Ligand-independent integrin beta1 signaling supports lung adenocarcinoma development
(2022-07-13)
Integrins, the principal extracellular matrix (ECM) receptors of the cell, promote cell adhesion, migration, and proliferation, which are key events for cancer growth and metastasis. To date, most integrin-targeted cancer ...
Self/tumor-reactive CD8 T cells enter a memory-like TCF1+ PD1- dysfunctional state
(2023-07-18)
T cells recognize several types of antigens in tumors, including aberrantly expressed, non-mutated proteins (self/shared-antigens; SSA) and mutated proteins or oncogenic viral proteins (tumor-specific antigens; TSA). ...
Self/tumor-reactive CD8 T cells enter a memory-like TCF1+ PD1- dysfunctional state
(2023-07-18)
T cells recognize several types of antigens in tumors, including aberrantly expressed, non-mutated proteins (self/shared-antigens; SSA) and mutated proteins or oncogenic viral proteins (tumor-specific antigens; TSA). ...