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Mathematical Modeling of Heterogeneity and Drug Response in Lung Cancer
(2018-09-24)
Technological advances have led to increasingly powerful and precise quantification of biological systems. These advances create a need for robust mathematical and computational approaches that are able to integrate complex ...
Understanding the Role of Smad4 in Intestinal Homeostasis and Tumorigenesis
(2014-07-31)
Colorectal carcinoma is the third leading cause of cancer related mortality within the United States. Over 90% of these deaths can be attributed to distant metastasis. Therefore, understanding the signaling perturbations ...
Insights into the Molecular Mechanisms of Phospholipase D-Mediated Cancer Cell Survival
(2014-02-11)
The production of bioactive lipids by phospholipases has long been appreciated as an important mode of cellular communication. Phospholipase D (PLD) enzymes hydrolyze phosphatidylcholine to generate a choline headgroup and ...
ALCAM Dynamically Regulates Tumor Cell Adhesion Through Differential Proteolysis and a Novel Binding Partner, Tetraspanin CD151
(2018-03-27)
Metastasis persists as a significant unsolved hurdle in cancer treatment, with greater than 90% of cancer-related deaths attributed to metastasis. In order for cells to successfully metastasize, they must dynamically ...
Predicting the Spatio-Temporal Evolution of Tumor Growth and Treatment Response in a Murine Model of Glioma
(2016-03-30)
Glioblastoma is a highly invasive and aggressive brain tumor which accounts for nearly 82% of all gliomas. Patients with glioblastoma typically have a poor prognosis, suffering recurrence 7 to 10 months from the conclusion ...
Optical imaging of cell cycle-driven tumor heterogeneity
(2016-03-30)
Metabolism-driven changes in cell cycle status introduce a high degree of cellular heterogeneity within a tumor, presenting challenges with evasion from drug treatment and increased likelihood of tumor recurrence. Accordingly, ...
Systems Biology of Mature Human B cells in Health and Illness
(2017-06-19)
B cells play a crucial role in adaptive immunity. They perform a multitude of functions including antibody and cytokine production and antigen presentation. The human adaptive immune response would not function effectively ...
Nicotinic Treatment of Post-Chemotherapy Subjective Cognitive Impairment
(2018-07-11)
Chemotherapy-related cognitive impairment (CRCI) is a quality of life issue that is commonly reported following the administration of chemotherapy in patients with cancer. Although studies reporting cognitive changes ...
A Computational Analysis on Gene Fusions in Human Cancer
(2014-07-22)
Gene fusions are instances where two discrete genes incorrectly join together. They are common mutations in cancer, and, since the advent of next generation sequencing technology, many gene fusions in cancer tissues have ...
Harnessing Non-invasive Imaging and Modeling towards Early Detection of Tumor Resistance to Targeted Therapy
(2017-02-03)
Clinical imaging and biopsies are major tools for cancer diagnosis. We explore whether serial imaging coupled with a mathematical model could test and refine patient specific forecasts for therapy outcomes.
We first ...