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Delineation of a novel Helicobacter pylori receptor, decay-accelerating factor
(2008-03-19)
Gastric adenocarcinoma is the second leading cause of cancer-related death in the world, and infection with Helicobacter pylori is the strongest known risk factor for this malignancy. Adherence of H. pylori to gastric ...
Medical information sources for cancer patients: Health care providers perspective
(2005-03-31)
Majority of Americans are paying moderate or a great deal of attention to medical health
news. The ability to clearly determine patients’ past and potential medical information sources
can help both physicians and patients ...
p120-catenin and p190RhoGAP regulate cell-cell adhesion by coordinating antagonism between Rac and Rho
(2007-04-06)
Integration of receptor tyrosine kinase, integrin, and cadherin activities is crucial for normal cell growth, motility and adhesion. Here, we describe novel roles for p120 catenin (p120) and p190RhoGAP that coordinate ...
Oxidative metabolism of exocyclic DNA adducts
(2008-03-13)
Multiple exocyclic DNA adducts arise from reactions of lipid and DNA peroxidation products with DNA bases. These endogenous lesions are mutagenic; therefore, monitoring adduct levels may provide a means of assessing genomic ...
Quantitative In Vitro and In Vivo Characterization of Near Infrared Molecular Imaging Agents for Enhanced Disease Detection
(2007-04-13)
The emerging field of molecular imaging (MI) aims to noninvasively, quantitatively and repetitively monitor biological processes in vivo to detect disease, probe its basis, and study relevant biochemical pathways at the ...
High Affinity Peptide Neurotoxin Quantum Dot Conjugates for Detecting Endogenous Targets in Live Cells and Ex Vivo Tissue
(2009-06-05)
This project focused upon advancing nanotechnology for applications in biological assays using highly fluorescent nanocrystals, quantum dots, with high affinity peptide neurotoxins as targeting molecules. Specifically, ...
In vivo characterization of the role of histone deacetylase 3 in metabolic and transcriptional regulation
(2008-05-30)
Histone deacetylase 3 (HDAC3) is the enzymatic component of transcriptional repression complexes recruited by the nuclear hormone receptors. Inactivation of HDAC3 in cancer cell lines triggered apoptosis, and removal of ...
Discovery and characterization of the mTOR-p73 signaling axis in human cancer
(2009-06-08)
p73, a transcription factor that plays essential roles during development and tumor suppression, shares significant sequence identity with p53. However, p53 and p73 are regulated by different pathways, and p73 is not ...
Cancer Support Groups as Subcultural Phenomena
(2004-12-17)
In this dissertation, I argue that cancer support groups may be usefully reconceptualized as subcultures with three distinct characteristics: ideology, norms and coping assistance. Ideology offers participants an alternative ...
Effect of MAPK inhibition on cell cycle regulation of thymidine kinase 1 and [18F]-FLT PET
(2009-12-14)
Positron emission tomography (PET) imaging using the radiotracer 3’-deoxy-3’-[18F]fluorothymidine ([18F]-FLT) has shown potential as a biomarker of proliferation in tumors. [18F]-FLT measures the activity of thymidine ...