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There and Back Again: A Protein’s Tale Uncovering the Quality Control Factors Mediating Peripheral Myelin Protein 22 Trafficking
(2020-11-02)
Charcot-Marie Tooth disease (CMTD) is the most common inherited neuropathy of the peripheral nervous system (PNS) and afflicts roughly 1 in 2,500 individuals. Over 70% of patients afflicted with this disease have a mutation ...
Interactions between Angiotensin II and Prostaglandin E2: Mechanisms for Regulation of Vascular Reactivity
(2016-08-05)
Prostaglandin E2 (PGE2), a cyclooxygenase metabolite that generally acts as a systemic vasodepressor, has been shown to have vasopressor effects under certain physiologic conditions. Previous studies have demonstrated that ...
The characterization of the role of myeloid translocation gene 16 in hematopoietic progenitor and stem cell functions
(2011-08-25)
The t(8;21) and t(16;21) that are associated with acute myeloid leukemia disrupt two closely related genes termed Myeloid Translocation Genes 8 (MTG8, also known as ETO) and 16 (MTG16 also known as ETO2), respectively. ...
Mechanistic details of the pH-dependent association of botulinum neurotoxin with membranes
(2011-09-06)
Botulinum neurotoxin (BoNT) belongs to a large class of toxic proteins that act by enzymatically modifying cytosolic substrates within eukaryotic cells. The process by which a catalytic moiety is transferred across a ...
Mechanisms by which calcium regulates the human cardiac voltage-gated sodium channel hH1
(2005-08-12)
The function of the human cardiac voltage-gated sodium channel hH1 is regulated in part by an EF-hand in its C-terminal cytoplasmic domain. The binding of calcium to the EF-hand results in calmodulin-independent, ...
Analysis of ErbB Receptors: Regulation of ErbB-1 Kinase Activation and Localization of ErbB-4 to Membrane Microdomains
(2007-10-03)
The ErbB family of receptor tyrosine kinases regulates cell growth, differentiation, and tumorigenesis. This dissertation contains two independent studies of ErbB-1 and ErbB-4. In one study, the intracellular juxtamembrane ...
Oncogenic KRAS and BRAF Drive Metabolic Reprogramming in Colorectal Cancer
(2016-11-15)
BIOCHEMISTRY
Oncogenic KRAS and BRAF Drive Metabolic Reprogramming in Colorectal Cancer
Josiah Ewing Hutton, III.
Dissertation under the direction of Professor Daniel C. Liebler
Analysis of cancer cells that have ...
Mechanisms of epidermal growth factor receptor tyrosine kinase activation and nuclear trafficking
(2009-09-04)
In several growth factor receptors, the intracellular juxtamembrane (JM) region participates in autoinhibitory interactions that must be disrupted for tyrosine kinase activation. Using alanine scanning mutagenesis, I ...
Spatially-Resolved Proteomics of the Human Lens: Mapping Age- and Development-Related Lens Protein Modifications
(2016-02-29)
The ocular lens is a transparent optical element that focuses light onto the retina for clear vision. The bulk of the lens is composed of elongated, anuclear fiber cells, which are continuously synthesized throughout life ...
Structural and Functional Analysis of Cyclooxygenase-2 Inhibition by Non-Steroidal Anti-Inflammatory Drugs
(2011-01-14)
The cyclooxygenase enzymes (COX-1 and COX-2) catalyze the conversion arachidonic acid (AA) to prostaglandin H2 (PGH2), which is the precursor to biologically active prostanoids. The primary mechanism of action of non-steroidal ...