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ETAA1 promotes genome stability through activation of ATR
(2018-11-21)
The ATR kinase controls cell cycle transitions and the DNA damage response. Budding yeast contain three activators of Mec1ATR; however, only TOPBP1 is known to activate ATR in vertebrates. We identified ETAA1 as a replication ...
Regulation of Stalled Replication Forks by ATR
(2014-04-17)
Errors during DNA replication lead to mutations which contribute to cancer development. To deal with these challenges, cells contain an innate machinery known as the replication stress response. ATR is the master regulator ...
Regulation of the ATR Pathway in the Replication Stress Response
(2016-07-15)
Every cell divisions cycle, over 6.8 billion base pairs of DNA must be accurately replicated. To further complicate this process, the DNA is damaged at a rate of ~10,000 lesions per cell per day. To overcome these obstacles, ...