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Development of combined Raman spectroscopy - optical coherence tomography for the detection of skin cancer
(2009-12-23)
Skin cancer is the most common cancer in the United States, with an incidence rate that continues to rise. Fortunately, it can be highly curable if detected at an early stage. Best clinical practices require physicians to ...
Effect of MAPK inhibition on cell cycle regulation of thymidine kinase 1 and [18F]-FLT PET
(2009-12-14)
Positron emission tomography (PET) imaging using the radiotracer 3’-deoxy-3’-[18F]fluorothymidine ([18F]-FLT) has shown potential as a biomarker of proliferation in tumors. [18F]-FLT measures the activity of thymidine ...
Discovery and characterization of the mTOR-p73 signaling axis in human cancer
(2009-06-08)
p73, a transcription factor that plays essential roles during development and tumor suppression, shares significant sequence identity with p53. However, p53 and p73 are regulated by different pathways, and p73 is not ...
High Affinity Peptide Neurotoxin Quantum Dot Conjugates for Detecting Endogenous Targets in Live Cells and Ex Vivo Tissue
(2009-06-05)
This project focused upon advancing nanotechnology for applications in biological assays using highly fluorescent nanocrystals, quantum dots, with high affinity peptide neurotoxins as targeting molecules. Specifically, ...