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Development of combined Raman spectroscopy - optical coherence tomography for the detection of skin cancer
(2009-12-23)
Skin cancer is the most common cancer in the United States, with an incidence rate that continues to rise. Fortunately, it can be highly curable if detected at an early stage. Best clinical practices require physicians to ...
Optical spectroscopy for the evaluation of surgical margin status following breast cancer resection
(2009-12-23)
The presence of tumor within 1-2 millimeters of the surgical margin following partial mastectomies is strongly correlated with the risk of local breast tumor recurrence; thus, there is a need to develop a non-invasive, ...
A Label-Free Method for the Determination of Polyethylene-Glycol Functionalization Efficiency on Gold Monolayer Protected Clusters
(2009-12-15)
Most bionanotechnology-based agents require careful control of surface properties to improve vascular circulation time, control delivery characteristics and provide biocompatibility, especially when used for diagnostics ...
A novel ratiometric method for determining the consequences of cell-size features in a concentration gradient generator
(2009-12-08)
We present a multi-dye ratiometric method for the correction of optical artifacts and unequal illumination encountered by researchers that utilize complex microfluidic systems. Using a novel chemotaxis system that provides ...
Iron Oxide Nanoclusters as In Vitro Biosensors of Proteolytic Activity
(2009-12-21)
We demonstrate a flexible, tunable scheme for synthesizing multifunctional, ultrasmall superparamagnetic iron oxide nanoparticles (USPIOs) and its application to the area of magnetic relaxation switches. USPIO cores (10nm) ...
A novel optical approach to the intraoperative detection of parathyroid glands
(2009-12-16)
A major challenge in endocrine surgery is the intraoperative identification of parathyroids during both thyroid and parathyroid surgery. Current localization techniques are mostly preoperative and are imprecise. Optical ...
Investigating tract-specific changes in white matter with diffusion tensor imaging
(2009-01-15)
Diffusion tensor imaging (DTI) is a magnetic resonance imaging (MRI) technique that provides information about the organization and structural integrity of tissue. It has become an increasingly popular tool for investigation ...
Development of a Novel Viral RNA Extraction Method
(2009-09-02)
Limitations of commercial RNA extraction kits make them inappropriate for use in a clinical setting. This project develops and evaluates a point-of-care process for simple and rapid extraction of RNA from clinical samples. ...
A finite element inverse analysis to assess functional improvement during the fracture healing process
(2009-10-28)
Assessment of the restoration of load-bearing function is the central goal in the study of fracture healing process. During the fracture healing, two critical aspects affect its analysis: (1) material properties of the ...
Compartmental Tissue Characterization using NMR Relaxometry
(2009-04-20)
Magnetic resonance imaging (MRI) is unique in its sensitivity to a wide array of contrast mechanisms in soft tissue. Unfortunately, the physiological and/or microanatomical characteristics that give rise to this contrast ...