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The development and genetic origin of broadly neutralizing HIV antibodies
(2012-07-30)
Several of the most broadly neutralizing HIV antibodies (bnAbs) contain unique genetic or structural elements, including long heavy chain complementarity determining region 3 (HCDR3) loops and extensive somatic hypermutation. ...
Object-Relevant Kinematics Influence Imitative Compatibility
(2012-07-31)
One critical finding from the literature on embodied cognition is that people produce actions more efficiently when observing similar as compared to when observing different actions. This imitative compatibility effect has ...
Analysis of Intestinal Splanchnopleure Development
(2012-08-06)
Mesothelium is a simple squamous epithelium that forms the surface layer of all coelomic cavities and organs. Despite its widespread localization, mesothelial development has been studied almost exclusively in the heart. ...
Quantum transport in nanodevices
(2012-08-12)
First-principles simulations of quantum transport in nano-devices are presented in this dissertation. First, the extension of the complex absorbing potential quantum transport framework to the general case of N electrodes ...
Posterior Hepatic Detection Using Ultrasound for Deformation Correction in Image Guided Liver Surgery
(2012-08-06)
This project involves the use of ultrasound imaging as a method to acquire posterior surface information intraoperatively for the use in deformation correction for image guided liver surgery. In this thesis, the subsurface ...
Regulation of PP2Ac stability – discovery of a novel α4 monoubiquitination-dependent mechanism that is altered in Alzheimer’s disease
(2012-12-01)
Studies described in this thesis identify a novel mechanism for α4’s regulation of PP2Ac stability. α4 binds the PP2A catalytic subunit (PP2Ac) and the microtubule-associated E3 ubiquitin ligase MID1, and through unknown ...
Resilient Cooperative Control of Networked Multi-Agent Systems
(2012-08-13)
Networked multi-agent systems consist of a set of agents that exchange information through a medium referred to as the network. The agents in the networked system are tasked with achieving certain group objectives. These ...
Multiscale Modeling of Brittle Composites Using Reduced Order Computational Homogenization
(2012-08-13)
This dissertation presents a novel multiscale computational framework for simulating failure and damage accumulation in brittle composites. A reduced-order multiple spatial scale methodology is developed to efficiently ...
Phosphoregulation of the Cdc25 phosphatase and its effects on Schizosaccharomyces pombe mitotic entrance and exit
(2012-08-22)
Cdk1 kinase dephosphorylation and activation by Cdc25 phosphatase is essential for mitotic entry. Activated Cdk1 phosphorylates Cdc25 and other substrates, further activating Cdc25 to form a positive feedback loop that ...
TGF-β1-induced calcification of valvular myofibroblasts: mechanisms and therapeutic strategies
(2012-08-31)
Aortic valve disease (AVD) is the third leading cause of cardiovascular disease and is especially prevalent among the elderly. In AVD, thickened fibrotic AV leaflets lose their ability to fully open and close, causing ...