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Exploring Zwitterionic Coronas as Alternatives to Traditional PEG Architectures for Improved siRNA Polyplex Pharmacokinetics and Tumor Delivery
(2016-11-21)
Although siRNA-based therapeutics hold great promise for systemic cancer treatment, polyplex nanocarrier systems face many intravenous challenges that limit their pharmacokinetic potential and therefore reduce tumor ...
Maximizing the Therapeutic Window and Elucidating the Toxicity Mechanisms of Intravenous siRNA Polyplex-Based Cancer Nanomedicines
(2019-07-08)
While siRNA nanomedicine holds great potential for unlocking otherwise “undruggable” targets, it also faces significant delivery challenges to non-liver targets such as tumors. In particular, polymeric delivery vehicles ...