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The Role of the Prostaglandin E2 EP3 Receptor in Obesity, Insulin Resistance, and Glycemic Control
(2015-12-01)
Mice carrying a targeted disruption of the prostaglandin E2 E-prostanoid receptor 3 (EP3) gene, Ptger3, were fed a high-fat diet (HFD), or a micronutrient matched control diet, to investigate the effects of disrupted ...
Autofluorescence Imaging Reflects Metabolic Response to Treatment in Human Head and Neck Squamous Cell Carcinoma
(2013-12-02)
Optical metabolic imaging measures fluorescence intensity and lifetimes from metabolic cofactors nicotinamide adenine dinucleotide (NADH) and flavin adenine dinucleotide (FAD). These molecular level measurements provide ...
13C metabolic flux analysis of recombinant Chinese hamster ovary (CHO) cell cultures
(2014-11-25)
We have applied 13C metabolic flux analysis (13C MFA) to develop a system-wide understanding of the central carbon metabolism of Chinese hamster ovary (CHO) cells, the most widely used host for industrial production of ...
The Skeletal Environment Dictates Staphylococcus aureus Virulence Responses and Mediates Metabolic Processes in Vivo
(2019-08-26)
S. aureus is the leading cause of infectious death in the United States. Although it innocuously colonizes up to one-third of the world’s population, S. aureus is capable of infiltrating nearly every organ in the human ...
Exploring the Function of G6PC2 in Pancreatic Islet Beta Cells
(2016-10-03)
MOLECULAR PHYSIOLOGY & BIOPHYSICS
Exploring the Function of G6PC2 in Pancreatic Islet Beta Cells
Kayla Boortz
Dissertation under the direction of Professor Richard O’Brien, Ph.D.
G6PC2 encodes an islet-specific ...
Bid Maintains Cell Viability and Homeostasis by Regulating Mitochondrial Physiology and the DNA Damage Response.
(2015-10-06)
Proteins of the Bcl-2 family mediate apoptosis by altering mitochondrial structure, function, and integrity. However, in certain contexts, some members of the Bcl-2 family have additional, non-apoptotic functions. Bid, a ...
Brain without Rictor: mTORC2 Signaling Regulates Central Dopamine Homeostasis
(2015-11-19)
Due to the escalating obesity epidemic in the United States, an important public health concern is the comorbidity of metabolic disorders and mental illness. Mounting clinical evidence supports the comorbid nature of mental ...
Cellular Metabolism in B cells: Roles of AMP-activated Protein Kinase, Glutamine, and Glucose Metabolism in Humoral Immunity
(2021-08-13)
Metabolism underpins many processes in cellular biology. Many diseases including cancer often involve aberrant metabolic pathways with altered reliance on metabolites, metabolic enzymes, or metabolic regulators. B lymphocytes ...
Modeling mammalian metabolism using novel stable isotopic techniques
(2021-08-16)
Biochemical methods to quantify gene transcript, enzyme, and metabolite levels are widely used to assess metabolic pathway regulation. Though informative and even vital in some contexts, static measurements of biomolecule ...
Characterization of the metabolic properties of brain microvascular endothelial cells
(2019-07-24)
The blood-brain barrier (BBB) is a highly restrictive and regulated vascular network, strictly controlling the molecules that enter the brain via the bloodstream, while also serving an important role in the removal of toxic ...