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DESIGN, DEVELOPMENT, AND MODELING OF PERFUSABLE HYDROGELS TO REGULATE CELL FATE AND BEHAVIOR IN 3D CONSTRUCTS
(2019-04-01)
Despite numerous promising preclinical in vivo models and several decades of clinical trials, the overwhelming majority of human drug trials have failed to translate into effective treatments for many diseases and disorders. ...
Unraveling the Role of Endoplasmic Reticulum Stress in Idiopathic Pulmonary Fibrosis (IPF)
(2019-01-15)
Endoplasmic reticulum (ER) stress in type II AECs has been associated with pathogenesis of IPF; however, factors inducing ER stress and downstream mechanisms through which ER stress impacts phenotype of type II AECs are ...
Exploring two new modalities of topoisomerase II-targeting drugs to enhance specificity for cancer cells
(2019-01-18)
Type II topoisomerases are enzymes that transiently cut the DNA to regulate supercoiling and remove knots and tangles from the genome. Although they are essential for cell survivability, these enzymes are potentially ...
Environmental Factishes, Variation, and Emergent Ontologies among the Matsigenka of the Peruvian Amazon
(2019-01-15)
Theories of environmental decision-making are based on “modern” conceptualizations of the world that are normalized and legitimized by scientific constructions of a reality that is assumed to be objective. Without recognizing ...
Tribological Examination of Alkylsilane Monolayer Films via Molecular Dynamics Simulation
(2019-01-16)
The lifetimes of micro- and nanoelectromechanical systems (MEMS/NEMS), devices featuring both electronic and mechanical components with feature lengths on the micro- to nanoscale, are threatened by friction and wear, often ...
SULFENYLATION OF CYTOCHROMES P450 IN RESPONSE TO REDOX ALTERATION
(2019-01-30)
Mammalian cytochrome P450 (P450) enzymes catalyze complex reactions involved in the biosynthesis of endogenous metabolites such as steroids, vitamins, and hormones. Additionally, several enzymes in this superfamily are ...
Dynamic Optical Metamaterials Based on Vanadium Dioxide
(2019-01-21)
The development of dynamically reconfigurable materials has long been a goal of the metamaterial community. Vanadium dioxide, a first-order phase change material, is a prime candidate for an actively tunable element as its ...
New Modes of B lymphocyte Regulation in Autoimmune Disease
(2019-01-17)
New Modes of B lymphocyte Regulation in Autoimmune Disease
Christopher Scott Wilson
Dissertation under the direction of Professor Daniel J. Moore
The deleterious roles that B lymphocytes play in autoimmunity and ...
Illuminating Molecular Mechanisms of Serotonin Transporter Regulation with Quantum Dot Single Particle Tracking
(2019-01-21)
The serotonin transporter protein (SERT) terminates serotonin signaling in the brain by enabling rapid clearance of the neurotransmitter. SERT dysfunction has been associated with a variety of psychiatric disorders, including ...
Next Generation Electrospun Nanofiber Electrodes for Hydrogen/Air Fuel Cells
(2019-01-28)
Fuel cells offer high energy-density and high power-density as sustainable, portable energy conversion devices. Obstacles to mass-market adoption of this technology include insufficient durability (power density retention ...