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Increased traction forces by cancer-associated fibroblasts align fibronectin to direct cancer cell migration
(2018-01-09)
Cancer-associated fibroblasts (CAFs) are major components of the carcinoma microenvironment that promote tumor progression. However, the mechanisms by which CAFs regulate cancer cell migration are poorly understood. In ...
AAPPL1 inhibits cell migration by modulating integrin trafficking and Rac signaling
(2018-02-14)
Cell migration is vital to numerous biological processes, and is misregulated in pathological processes, such as cancer metastasis. Cell migration is a tightly, spatiotemporally regulated process that requires the coordination ...
The Impact of Host-Microbe Interactions on Nasonia Evolution
(2018-10-05)
The interactions between a host and its associated microbes can convey either beneficial or harmful traits on the host, such as dietary supplementation or reproductive parasitism, respectively. Through host interactions ...
microRNA Function in Zebrafish Development and Regeneration
(2018-10-23)
microRNAs (miRNAs) are a family of highly conserved small noncoding RNAs that post transcriptionally regulate gene expression and play important roles in many cellular processes during development and regeneration. The ...
Regulation of membrane asymmetry by Golgi P4-ATPases and their interactors
(2018-11-12)
Neo1 was discovered in a multi-copy suppressor screen in Saccharomyces cerevisiae to search for factors conferring resistance against an aminoglycoside antibiotic, neomycin (1). Aminoglycoside antibiotics, used to treat ...
Genestation: The Genomic Search Engine Toolkit
(2018-10-19)
Recent advances in sequencing technology have greatly decreased the cost and increased the availability of genomic data. Armed with this rich base of information, it has become feasible to pursue the study of complex ...
Structural and Functional Studies of AP4 and its Accessory Protein Tepsin
(2018-03-26)
The adaptor protein 4 (AP4) heterotetrameric complex helps form vesicles and traffic cargo from the trans-Golgi Network. Tepsin, a member of the epsin family of trafficking proteins, is the only known accessory protein of ...
Matrix Metalloproteinase Requirements for Neuromuscular Synaptogenesis
(2018-01-16)
Synaptogenesis requires coordinated intercellular communication between a presynaptic neuron and postsynaptic target cell. Neural development and maintenance is driven by a wide variety of molecules that necessarily traverse ...
Replication Fork Remodeling by Helicase-Like Transcription Factor
(2018-06-26)
During DNA replication, a moving replication fork can encounter various sources of replication stress that can lead the moving fork to stall. Organisms have developed various DNA damage response pathways that recruit and ...
Neural Network Adaptation in the Retina: Dopaminergic Signaling Mechanisms
(2018-04-04)
The initial steps of vision - the transduction and encoding of physical light stimuli into neural signals - occur in the retina, a multi-layered sheet of neurons that lines the back of the eye. Retinal dopamine (DA) acts ...