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The Study of Cancer Cell Heterogeneity, by Image-based Migration Analysis
(2009-08-11)
Genetic heterogeneity is a key factor involved in tumor progression, and it is increasingly recognized that heterogeneity of phenotypic traits exists among individual cancer cells. In this dissertation, I investigate the ...
Brønsted acid promoted additions of diazoalkanes to imines: the interplay of mechanism and stereochemical outcome as a tool to discover and develop a new syn glycolate Mannich reaction
(2009-10-05)
The 1,2-amino alcohol is a prevalent motif in natural products with biological activity. Many synthetic methods exist for the synthesis of 1,2-amino alcohols. Yet few are capable of setting both stereocenters in a single ...
An architectonic study of three mammals: grey squirrels (Sciurus carolinesis), tree shrews (Tupaia belangeri) and galagos (Otolemur garnetti)
(2009-08-26)
Studies of cortical architecture have been used to subdivide cortex into areas of presumed functional significance and reveal features of areal differentiations across species. In the present studies, cortical architectures ...
Part-term Learning in Preschool Children with Low Socioeconomic Status
(2009-08-21)
The goal of this study was to examine word learning in preschool children with low socioeconomic status (SES) to inform an understanding of the limited word knowledge of this population. There is evidence to suggest that ...
A generalized single-event analysis and hardening options for mixed-signal phase-locked loop circuits
(2009-08-27)
A reliability concern of growing interest in the microelectronics community is the deleterious effect of ionizing radiation. The so-called "single events" – single particles which can penetrate semiconductor material ...
Changing Media, Chaning Minds: The Lesbian and Gay Movement, Television, and Public Opinion
(2009-08-26)
Continuity tends to characterize political attitudes with parents tending to transmit their opinions to their offspring. Given these orthodox conceptions, why have attitudes towards lesbians and gays liberalized in recent ...
Mechanisms of epidermal growth factor receptor tyrosine kinase activation and nuclear trafficking
(2009-09-04)
In several growth factor receptors, the intracellular juxtamembrane (JM) region participates in autoinhibitory interactions that must be disrupted for tyrosine kinase activation. Using alanine scanning mutagenesis, I ...
Development of a Novel Viral RNA Extraction Method
(2009-09-02)
Limitations of commercial RNA extraction kits make them inappropriate for use in a clinical setting. This project develops and evaluates a point-of-care process for simple and rapid extraction of RNA from clinical samples. ...
A Powered Self-Contained Knee and Ankle Prosthesis for Near Normal Gait in Transfemoral Amputees
(2009-07-25)
The human leg serves as the primary mechanism to provide locomotion and general mobility, both of which require significant power generation at the joints. Today, commercial lower limb prostheses are generally passive ...
Model Based Performance Testing of Distributed Large Scale Systems
(2009-07-25)
Size and complexity of software systems are increasing and there is increasing demand for component based distributed applications and systems. Performance characteristics such as throughput and scalability are crucial ...