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Now showing items 71-80 of 289
An expert system for stress analysis of human teeth
(2009-02-23)
A general computational model for describing the stress state for any shape tooth under any loading conditions is presented. The model is constructed based on tooth type, dimensions, materials, loads, boundary conditions, ...
Effects of single-event-induced charge sharing in sub-100 nm bulk CMOS technologies
(2009-02-16)
Sub-100 nm technologies are more vulnerable than older technologies to single event effects (SEE) due to Moore's Law scaling trend. The increased SEE vulnerability has been attributed to the decrease in nodal charge for ...
Structural and functional determinants of effective CD8+ T cell suppression of HIV-1 replication
(2009-03-28)
CD8+ T cells are a critical component of an HIV-specific immune response. Our studies aimed to define the T cell receptor (TCR) structural determinants as well as effector functions associated with CD8+ T cell suppression ...
Helicobacter pylori-mediated dysregulation of p120-catenin and matrix metalloproteinase-7
(2009-03-03)
Gastric adenocarcinoma is strongly associated with the presence of H. pylori, and both microbial and host factors influence the risk for carcinogenesis. A novel role for H. pylori in the stimulation of the p120ctn/Kaiso ...
A Knowledge-Driven Multi-Locus Analysis of Multiple Sclerosis Susceptiblity
(2009-03-12)
Evaluating epistasis in whole-genome association studies is an important challenge in human genetics, as many common diseases are thought to have complex underlying genetic architectures that include small independent ...
Tbx2b is required for parapineal organogenesis
(2009-03-13)
The existence of anatomical differences along the left-right (L-R) axis in the brain and visceral organs is an evolutionarily conserved feature of the vertebrate lineage. Although much is known about the molecular pathways ...
Development of High-Brightness Electron Sources for Free-Electron Lasers
(2009-03-12)
The primary purpose of this thesis is to detail recent progress in the development of high-brightness cathodes for use in beam driven radiation sources. In particular, diamond field-emitter arrays (DFEA) are discussed and ...
Electrophoretic separations of monolayer protected clusters
(2009-07-29)
The determination of electrophoretic properties and the size separation of monolayer protected clusters (MPCs) are presented in this thesis. MPCs are metallic nanoparticles encapsulated in a protecting thiolate monolayer. ...
The regulation of net hepatic glucose uptake by nitric oxide and serotonin in vivo
(2009-07-28)
This dissertation focused on effects of the biological mediators, nitric oxide (NO) and serotonin in the regulation of net hepatic glucose uptake (NHGU). This work demonstrated that NHGU was suppressed by an increase in ...
Design and Implementation of an Advanced Spill Management Information System for Surface Waters
(2009-07-30)
This research involved the development of a new information system to improve inland waterway spill response. A review of current decision-support tools used to aid in spill response suggested that improvements were needed. ...