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Role of Invariant Natural Killer T Cells in Tularemia-like Disease in Mice
(2015-11-13)
The respiratory mucosa is a major site for pathogen invasion and, hence, a site requiring constant immune surveillance. The type I, semi-invariant natural killer T (iNKT) cells are enriched within the lung vasculature. ...
Targeting Notch3 signaling in lung cancer
(2011-11-08)
Dysregulation of the Notch signaling pathway plays an important role in lung cancer pathobiology. The Notch3 receptor is overexpressed in ∼40% of resected non-small cell lung cancers, and its suppression results in loss ...
A chemical genetic approach to interrogate the staphylococcal heme sensing system
(2016-11-23)
Staphylococcus aureus is a Gram-positive pathogen that contributes to significant morbidity and mortality worldwide. In order to successfully colonize the host, S. aureus requires heme as a nutrient iron source and as a ...
Novel stable isotope methods to quantify glucose metabolism
(2016-11-18)
The development, validation, and application of novel methods to quantify glucose metabolism are presented in this thesis. The methodologies use stable isotope tracers, gas chromatography-mass spectrometry, and mathematical ...
Single event latchup: hardening strategies, triggering mechanisms, and testing considerations
(2012-11-05)
Single event latchup (SEL) is a serious reliability concern for CMOS integrated circuits (ICs), and can be especially problematic in the space radiation environment. It can occur because of a parasitic pnpn circuit inherent ...
Development of a Spatially Multiplexed Ion Mobility Spectrometer and Utilization of Ion Mobility-Mass Spectrometry for Conformational Analyses of Lipids and Other Biomolecules
(2018-03-27)
The aim of this research was to develop strategies to advance ion mobility-mass spectrometry (IM-MS) studies via both the development of a novel, spatially multiplexed instrument and the conformational analyses of biomolecules, ...
Improving membrane protein modeling and design using empirical data
(2018-03-26)
Membrane proteins are an important class of proteins that represent approximately 30% of the open reading frame. However, due to their inherent flexibility, membrane proteins are difficult to structurally characterize, ...
Privacy Leaks and Efficient Countermeasures for Human Genetics and Machine Learning
(2018-04-06)
Modern scientific investigations have increasingly relied upon the expanded collection and analysis of data (“big data”). In the genetics community, there is evidence to suggest that increased statistical power can be ...
Human antibody response to zoonotic influenza A viruses
(2018-04-02)
Annual outbreaks of influenza A viruses in humans are one of the major health problems worldwide, causing more than 250,000 deaths every year. In addition to yearly epidemics, novel influenza viruses that cross the species ...
Adaptive Multiplexed RT-PCR Assay for Detection of Chikungunya, Dengue, and Zika Viruses
(2018-03-26)
As chikungunya, dengue, and Zika virus infections all present similar symptoms, a multiplexed assay could provide enhanced diagnostic power to clinicians at the point-of-care in low-resource settings: a patient with these ...