Browsing Electronic Theses and Dissertations by Author "Macara, Ian"

Now showing items 1-4 of 4

    • Investigating the molecular mechanisms of microtubule catastrophe 
      Farmer, Veronica Jeanne; 0000-0003-3857-5793 (2022-03-29)
      Department: Cell & Developmental Biology
      The microtubule network in cells continuously remodels to facilitate its vital functions in cell division, cell motility and intracellular transport. Organization of the microtubule network is enabled by regulation of the ...
    • Modeling Alternating Hemiplegia of Childhood with iPSC-Derived Neurons 
      Snow, John Patrick; 0000-0002-8569-1431 (2020-05-14)
      Department: Cell & Developmental Biology
      Alternating hemiplegia of childhood (AHC) is a rare and devastating neurodevelopmental disorder caused by de novo heterozygous missense mutations in ATP1A3, a crucial gene encoding the 3 subunit of the Na,K-ATPase (NKA) ...
    • Revealing MCL-1 Regulation of Mitochondrial Dynamics in Human Pluripotent Stem Cell-Derived Systems 
      Rasmussen, Megan Loraine; 0000-0002-8056-6092 (2021-02-03)
      Department: Cell & Developmental Biology
      The B cell CLL/lymphoma-2 (BCL-2) family of proteins control the mitochondrial pathway of cell death, also known as intrinsic apoptosis. The ability of the cell to sense stress and translate it into a death signal has been ...
    • TRANSCRIPTION FACTOR RFX3 STABILIZES MAMMARY BASAL CELL IDENTITY 
      Artis, Erica; 0000-0002-1560-323X (2022-03-29)
      Department: Cell & Developmental Biology
      The myoepithelial cell compartment of the murine postnatal mammary gland is generated from basal cap cells in the terminal end bud and maintained by self-renewal. Transdifferentiation to the luminal lineage does not normally ...