Browsing Electronic Theses and Dissertations by Title
Now showing items 3258-3277 of 6988
-
(2014-08-01)Department: Learning, Teaching and DiversityRecently, the field of science education has advocated for systematic explorations of the affordances of an integrated STEM education. Accordingly, in this three-paper dissertation I investigate how students build conceptual ...
-
(2012-12-03)Department: Chemical and Physical BiologyiASPP (inhibitory member of the apoptosis stimulating protein of p53 family) is known to inhibit the important tumor suppressors p53 and p73. Indeed, iASPP is over-expressed in several cancer types and is associated with ...
-
(2022-11-02)Department: NeuroscienceThis dissertation aimed to investigate behavioral symptoms commonly encountered in conditions that present with motor symptoms. These studies primarily focused on the pathophysiology of impulsive and compulsive behaviors ...
-
Investigating Kinesin-based Mitotic Spindle Assembly Backup Mechanisms Using Single Molecule Methods (2018-04-02)Department: Chemical EngineeringMolecular motors are essential to sustain life, carrying out cellular processes that require directed motion over diffusion. Kinesins are motors that use ATP hydrolysis to perform mechanical work. Mitotic kinesins generate ...
-
(2011-12-01)Department: Human GeneticsAbnormal regulation of mitochondrial deoxyribonucleoside triphosphate pools can lead to mitochondrial DNA depletion syndromes, a set of genetic diseases associated with depletion of mitochondrial DNA. Besides mitochondrial ...
-
(2010-09-21)Department: Cell and Developmental BiologyThis dissertation project was aimed at elucidating cellular and molecular responses to myocardial infarction. Our work identified canonical wnt signaling as a molecular pathway that is induced in the healing (granulation ...
-
(2020-04-02)Department: Computer ScienceAlongside the ever-growing influence of convolutional neural networks(CNN) in the image classification task, its capability for working robustly with noisy images will become more critical. A practical classification system ...
-
(2019-10-17)Department: Microbiology and ImmunologyEmerging viruses, such as coronaviruses (CoVs), continue to pose a threat to human health, and few countermeasures have been approved to treat these infections. Two CoVs have emerged to cause severe disease in humans within ...
-
(2017-02-23)Department: Microbiology and ImmunologyBacteria use two-component system (TCS) signaling to sense and respond to their ever-changing surroundings. While most TCSs have been reported to interact solely as a cognate partner pair, one sensor kinase phosphorylating ...
-
(2017-03-27)Department: Learning, Teaching and DiversitySeveral studies have identified positive relationships between strong principal instructional leadership and improved student outcomes. However, few researchers have examined how principals influence the nature of ...
-
(2019-07-11)Department: PsychologyDirect and indirect self-harm behaviors frequently co-occur, suggesting possible common factors in their etiology. Theoretical models of two such behaviors, nonsuicidal self-injury (NSSI) and disordered eating (DE), implicate ...
-
(2022-07-20)Department: Interdisciplinary Materials ScienceAmmonia (NH3) is a vital chemical to the agricultural and explosives industries, and it may very well play a central role in the emerging hydrogen economy. The Haber-Bosch process has long been the method used to synthesize ...
-
(2012-07-31)Department: Chemical EngineeringThe conversion of plant biomass to fermentable sugars is a primary option for the production of biofuels. Cellulases, the enzymes that break down recalcitrant plant cellulose materials into fermentable sugars, can be ...
-
(2009-04-13)Department: AnthropologyThis dissertation investigates the relationship between power and wealth in past societies by examining the economic networks through which wealth was distributed at K’o, Guatemala from the Terminal Preclassic through the ...
-
(2011-10-31)Department: BiochemistryThe integrity and propagation of the genome depends upon the fidelity of DNA processing events such as replication, damage recognition, and repair. Requisite to the numerous biochemical tasks required for DNA processing ...
-
(2016-04-08)Department: Interdisciplinary Studies: Analytical PharmacologyEicosanoids, such as prostaglandins, leukotrienes, hydroxy- and epoxy-derivatives of arachidonic acid (AA), are lipid autacoids that regulate constitutive as well as inflammatory processes. Prostaglandins (PGs) and ...
-
(2022-05-16)Department: Cancer BiologyLung adenocarcinoma (LUAD) is a heterogeneous group of tumors associated with different survival rates, even when detected at an early stage. While screening programs have proven to significantly increase the chance of ...
-
(2023-11-09)Department: Human GeneticsCoronary artery disease (CAD) and depression are highly prevalent and frequently comorbid. Approximately 40% of adults who are initially diagnosed with either CAD or depression will also develop the other condition. Moreover, ...
-
(2020-06-16)Department: Cell & Developmental BiologyHuman casein kinase 1 delta (CK1δ) and epsilon (CK1ε) are members of a conserved family of ubiquitously expressed serine/threonine kinases that regulate multiple cellular processes including endocytosis, circadian rhythm, ...
-
(2014-11-24)Department: Psychology“Groupitizing,” or the ability to quickly enumerate an array of items that is grouped into subitizable subsets, has recently been shown to predict children’s symbolic math skills. It has been proposed that groupitizing ...