Browsing Research Reports by Title

Now showing items 1-11 of 11

Apical Shear Stress Enhanced Organic Cation Transport in Human OCT2/MATE1-Transfected Madin-Darby Canine Kidney Cells Involves Ciliary Sensing

Jayagopal, Aishwarya; Brakeman, Paul R.; Soler, Peter; Ferrell, Nicholas; Fissell, William; Kroetz, Deanna L.; Roy, Shuvo (Journal of Pharmacology and Experimental Therapeutics, 2019-06-01)

Active transport by renal proximal tubules plays a significant role in drug disposition. During drug development, estimates of renal excretion are essential to dose determination. Kidney bioreactors that reproduce physiologic ...
An Evaluation of Longitudinal Measures of Anticholinergic Exposure for Application in Retrospective Administrative Data Analyses

Dmochowski, Roger (Advances in Therapy, 2019-09)

Introduction As continuous exposure to anticholinergics has been associated with adverse outcomes, accurately measuring exposure is important. However, no gold standard measure is available, and the performance of existing ...
Gene Dose-Dependent and Additive Effects of ABCG2 rs2231142 and SLC2A9 rs3733591 Genetic Polymorphisms on Serum Uric Acid Levels

Park, Jin-Woo; Noh, Ji-Hyeon; Kim, Jong-Min; Lee, Hwa-Young; Kim, Kyoung-Ah; Park, Ji-Young (Metabolites, 2022-11-29)

This study aimed to evaluate whether the single nucleotide polymorphisms of ATP-binding cassette subfamily G member 2 (ABCG2) and solute carrier family 2 member 9 (SLC2A9) affect individual blood uric acid levels using ...
Gene Dose-Dependent and Additive Effects of ABCG2 rs2231142 and SLC2A9 rs3733591 Genetic Polymorphisms on Serum Uric Acid Levels

Park, Jin-Woo; Noh, Ji-Hyeon; Lee, Hwa-Young; Park, Ji-Young (Metabolites, 2022-11-29)

This study aimed to evaluate whether the single nucleotide polymorphisms of ATP-binding cassette subfamily G member 2 (ABCG2) and solute carrier family 2 member 9 (SLC2A9) affect individual blood uric acid levels using ...
Key Mechanisms by Which Post-ICU Activities can Improve in-ICU Care: Results of the International THRIVE Collaboratives

Boehn, Leanne M.; Sevin, Carla M. (INTENSIVE CARE MEDICINE, 2019-07)

ObjectiveTo identify the key mechanisms that clinicians perceive improve care in the intensive care unit (ICU), as a result of their involvement in post-ICU programs.MethodsQualitative inquiry via focus groups and interviews ...
Long-Chain and Medium-Chain Fatty Acids in Energy Metabolism of Murine Kidney Mitochondria

Panov, Alexander V. V.; Mayorov, Vladimir I. I.; Dikalova, Anna E. E.; Dikalov, Sergey I. I. (International Journal Of Molecular Sciences, 2022-12-26)

Scientists have long established that fatty acids are the primary substrates for kidney mitochondria. However, to date we still do not know how long-chain and middle-chain fatty acids are oxidized at the mitochondrial ...
PEGylated PLGA Nanoparticle Delivery of Eggmanone for T Cell Modulation: Applications in Rheumatic Autoimmunity

Haycook, Christopher P.; Balsamo, Joseph A.; Glass, Evan B.; Williams, Charles H.; Hong, Charles C.; Major, Amy S.; Giorgio, Todd D. (International Journal of Nanomedicine, 2020)

Background: Helper T cell activity is dysregulated in a number of diseases including those associated with rheumatic autoimmunity. Treatment options are limited and usually consist of systemic immune suppression, resulting ...
The Rural VA Multi-Center Medication Reconciliation Quality Improvement Study (R-VA-MARQUIS)

Presley, Caroline A.; Wooldridge, Kathleene T.; Byerly, Susan H.; Aylor, Amy R.; Kaboli, Peter J.; Roumie, Christianne L.; Schnipper, Jeffrey L.; Dittus, Robert S.; Mixon, Amanda S. (American Journal of Health-System Pharmacy, 2020-01-15)

Purpose High-quality medication reconciliation reduces medication discrepancies, but smaller hospitals serving rural patients may have difficulty implementing this because of limited resources. We sought to adapt and ...
Safety, tolerability, and pharmacokinetics of repeated oral doses of 2-hydroxybenzylamine acetate in healthy volunteers: a double-blind, randomized, placebo-controlled clinical trial

Pitchford, Lisa M.; Driver, Patricia M.; Fuller, John C., Jr.; Akers, Wendell S.; Abumrad, Naji N.; Amarnath, Venkataraman; Milne, Ginger L.; Chen, Sheau-Chiann; Ye, Fei; Roberts, L. Jackson, II; Shoemaker, M. Benjamin; Oates, John A.; Rathmacher, John A.; Boutaud, Olivier (BMC Pharmacology & Toxicology, 2020-01-06)

Background 2-Hydroxybenzylamine (2-HOBA) is a selective dicarbonyl electrophile scavenger being developed as a nutritional supplement to help protect against the development of conditions associated with dicarbonyl ...
Th1-type immune responses to Porphyromonas gingivalis antigens exacerbate angiotensin II-dependent hypertension and vascular dysfunction

Czesnikiewicz-Guzik, Marta; Nosalski, Ryszard; Mikolajczyk, Tomasz P.; Vidler, Francesca; Dohnal, Tomasz; Dembowska, Elzbieta; Graham, Delyth; Harrison, David G.; Guzik, Tomasz J. (British Journal of Pharmacology, 2019-06)

Background and Purpose Emerging evidence indicates that hypertension is mediated by immune mechanisms. We hypothesized that exposure to Porphyromonas gingivalis antigens, commonly encountered in periodontal disease, can ...
When Blood Pressure Increases with Standing: Consensus Definition for Diagnosing Orthostatic Hypertension

Jordan, Jens; Biaggioni, Italo; Grassi, Guido; Fedorowski, Artur; Kario, Kazuomi (Blood Pressure, 2023-01-03)